Atorvastatin
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Autoimmune necrotising myopathy: case report A 62-year-old woman developed autoimmune necrotising myopathy during treatment with atorvastatin for hyperlipidaemia. The woman, who had a history of coronary artery disease, chronic obstructive pulmonary disease, hypertension and hyperlipidaemia, was receiving atorvastatin 80mg daily [route not stated] over a period of past 5 years without modification in dose. She presented with a few weeks history of progressive weakness, myalgia, acute on chronic dysphagia, voice change and recurrent falls. At the time of current presentation, her creatine kinase level was 5592 IU/L. Atorvastatin was stopped. The woman rapidly exhibited diffuse weakness with 2-3/5 strength in the upper and lower extremities. She was admitted in the ICU for acute hypoxic and hypercarbic respiratory failure. Muscle biopsy showed significant muscle necrosis. Electromyogram showed diffuse abnormalities in sensory and motor conduction amplitudes. She received methylprednisolone [Solumedrol] for three days and immune-globulin [IVIG] for presumed atorvastatin-induced autoimmune necrotising myopathy. Her muscle weakness improved gradually, and respiratory failure resolved. She continued receiving prednisone and immune-globulin in addition to methotrexate [not all outcomes stated]. Gillespie M, et al. A case of antibody negative statin induced myopathy resulting in acute respiratory failure. American Journal of Respiratory and Critical Care Medicine 199: 803446482 (plus poster) abstr. A1796, No. 9, May 2019. Available from: URL: https://doi.org/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A1796 [abstract]
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Reactions 18 Jan 2020 No. 1787
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