Atorvastatin
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Atorvastatin Eosinophilia: case report A 60-year-old man developed eosinophilia following treatment with atorvastatin for atherosclerosis and hyperlipidaemia. The man was diagnosed with hyperlipidaemia, atherosclerosis and type 2 diabetes; he was administered atorvastatin 20mg once daily [route not stated] in addition to valsartan, thiamine [vitamin B1], vitamin B12 and pain relieving paste. His blood eosinophil values were normal prior to atorvastatin initiation. One week after initiating atorvastatin, worsening abdominal pain ensued. Tests performed 2 months after starting atorvastatin, revealed an eosinophil count of 2.32 × 109/L with an eosinophil percentage of 20.5%. Vitamin B12, thiamine, pain relieving paste and valsartan were withdrawn. Atorvastatin was continued, and after 4 months of receiving atorvastatin repeat tests showed an eosinophil percentage of 30.1% with an eosinophil count of 4.39 × 109/L. Atorvastatin was withdrawn, and the man’s eosinophil values improved. After 1.5 months, his eosinophil count was 0.33 × 109/L with a eosinophil percentage of 3.1%. Rosuvastatin calcium was initiated; at follow-up, 2 months later, eosinophil values remained normal. Author comment: "After atorvastatin was discontinued for 1.5 months, re-examination showed the Eos count was completely restored to normal, indicating atorvastatin is the cause of eosinophilia." Tang R, et al. One case of eosinophilia caused by atorvastatin. Chinese Medical Journal 126: 3994-3995, No. 20, Jan 2013. Available from: URL: http:// 803096057 dx.doi.org/10.3760/cma.j.issn.0366-6999.20130966 - China
0114-9954/13/1480-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Reactions 30 Nov 2013 No. 1480
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