Biogenic Synthesis of Rod Shaped ZnO Nanoparticles Using Red Paprika ( Capsicum annuum L. var. grossum (L.) Sendt) and T
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ORIGINAL PAPER
Biogenic Synthesis of Rod Shaped ZnO Nanoparticles Using Red Paprika (Capsicum annuum L. var. grossum (L.) Sendt) and Their in Vitro Evaluation Sekar Vijayakumar1,2 • Zaira I. Gonza´lez-Sa´nchez3 • Balasubramanian Malaikozhundan4 • Kandasamy Saravanakumar1 • Mani Divya2 • Baskaralingam Vaseeharan2 • Esteban F. Dura´n-Lara5,6 Myeong-Hyeon Wang1
•
Received: 3 April 2020 Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Metal oxide nanoparticles (NPs) have gained attention in biomedicine due to their broad spectrum of applications, such as targeted drug delivery, their use as antibacterial agents or in cancer treatments. In particular, zinc oxide nanoparticles (ZnO NPs) have become one of the most popular metal oxide NPs in biomedical applications. The present study describes for the first time the biogenic synthesis of rod shaped ZnO NPs using C. annuum L. var. grossum (L.) Sendt) extract as a capping agent. The purified C. annum-based zinc oxide nanorods (Ca-ZnO NRs) were characterized by different physico-chemical techniques. UV–vis spectroscopy depicted the absorbance peak at 372 nm. The size of nanorods ranges between 70 and 80 nm as revealed by FE-TEM micrographs and the mean size was 72 nm. Ca-ZnO NRs exhibited antibacterial activity in a dose-dependent manner and a greater activity was observed against S. enterica. Ca-ZnO NRs have shown antioxidant activity (91%) at 100 lg ml-1 when compared to the standard (ascorbic acid) (98%). A significant inhibition of bovine serum albumin (BSA) protein denaturation evidenced their anti-inflammatory property. Further, Ca-ZnO NRs showed hemolysis of red blood cells (RBC) (* 3%) (up to 3 lg ml-1) which is much lesser than permissible limit. Keywords Capsicum annuum ZnO Nanorods Antibacterial Antioxidant Biocompatibility
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10876-020-01870-z) contains supplementary material, which is available to authorized users.
Nanotechnology is an emerging science that has proven promise in humanizing several life features ranging from medicine to industrial applications. Recently, bio 3
Nanobiology Laboratory, Department of Natural and Exact Sciences, Pontificia Universidad Cato´lica Madre y Maestra, PUCMM, Autopista Duarte Km 1, Santiago de los Caballeros, Dominican Republic
4
Department of Biology, The Gandhigram Rural Institute (Deemed to be University), Dindigul District, Gandhigram, Tamil Nadu 624 302, India
5
Bio & NanoMaterials Lab| Drug Delivery and Controlled Release, Universidad de Talca, 3460000 Talca, Maule, Chile
6
Departamento de Microbiologı´a, Facultad de Ciencias de la Salud, Universidad de Talca, 3460000 Talca, Maule, Chile
& Sekar Vijayakumar [email protected] & Myeong-Hyeon Wang [email protected] 1
2
Department of Medical Biotechnology, College of Biomedical Sciences, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea N
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