Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics
Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. Reverse genetics, a technique that allows generation of recombinant viruses, was first developed for negative-stra
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Editors R. W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel· M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo • M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California · H. Wagner, Munich
Springer-Verlag Berlin Heidelberg GmbH
Y. Kawaoka (Ed.)
Biology of
Negative Strand RNA Viruses: The Power of Reverse Genetics
With 19 Figures and 7 Tables
Springer
Professor Yoshihiro Kawaoka, DVM, PhD University ofWisconsin-Madison School of Veterinary Medicine Department of Pathobiological Sciences 2015 Linden Drive West Madison, Wisconsin 535706 USA e-mail: Kawaokay@svm. vetmed. wisc.edu Cover Illustration by Yuko Kawaoka: Generation of negative strand RNA virus from cloned cDNA.
ISSN 0070-217X ISBN 978-3-642-07375-5 ISBN 978-3-662-06099-5 (eBook) DOI 10.1007/978-3-662-06099-5 Library of Congress Catalog Card Number 72-152360 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-VerlagBerlinHeide1bergGmbH. Violations are liable for prosecution under the German Copyright Law. springeronline.com © Springer-Verlag Berlin Heidelberg 2004
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Preface
Viruses consist of genetic information and components that help to maintain the integrity of this information through replication, packaging, and transmission. Each major class of viruses occupies its own niche, distinguished by the shape, host range, and type of genetic information common to its members. Negative-strand RNA viruses are characterized by the polarity of their genomic RNA to mRNA and by their involvement in diseases of medical and veterinary importance. Moreover, many representatives of this class, exemplified by Ebola and Nipah viruses, are considered emerging pathogens, and other viruses are awaiting discovery. Remarkable progress in understanding negative-strand RNA viruses has come through reverse genetics, a technology that allows one to generate viruses possessing genes derived from cloned
