Biology of Stem Cells and the Molecular Basis of the Stem State
Biology of Stem Cells and the Molecular Basis of the Stem State concentrates upon adult stem cells, particularly on mesenchymal cell populations, which are the author’s area of expertise. The text offers the reader a detailed description of the emergence
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Dov Zipori
Biology of Stem Cells and the Molecular Basis of the Stem State
Dov Zipori Department of Molecular Cell Biology Weizmann Institute of Science 76100 Rehovot Israel [email protected]
ISBN 978-1-60761-129-5 e-ISBN 978-1-60761-130-1 DOI 10.1007/978-1-60761-130-1 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009927132 © Humana Press, a part of Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
This monograph is dedicated to my beloved wife Gala, for painting my life in bright colors, and to my children Sigal and Dan Zipori, whose creativity makes me proud. And to the memory of my parents, Dina (Magda) and Haim Simon Zipori, role models, who taught me to stick to my beliefs, no matter what, and to the memory of my best friend, the late Avraham (Rami) Itschak Kook, who was always there for me in the worst and best of times.
Preface
Stem cell research is, undoubtedly, one of the most exiting fields of contemporary biology. A major motivation I had for undertaking the writing of this monograph is my having witnessed the development of this field over the past 38 years. I would like to share my thoughts during this lengthy period, with those who are currently studying stem cells. I believe that better understanding of the conceptual steps in the emergence of stem cell dogmas, may prompt some readers to undertake new venues of research. The above is, however, only one reason for this undertaking. I am deeply concerned by the popularization of stem cell notions; in the interest of exposing the public to stem cell issues, intellectual compromises have been made. Some issues in stem cell biology are very difficult to convey. Major subjects in stem cell biology are therefore portrayed in a naïve manner, which is often only remotely accurate. To my dismay, several such oversimplified ideas concerning stem cells have diffused from the general public back to the research community, and affected the thinking of many. I decided therefore to write a monograph of a critical nature. It does not deal with the promotion of current conventions, but rather, presents altern
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