Biomarkers for Endometriosis State of the Art
This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomark
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Biomarkers for Endometriosis State of the Art
Biomarkers for Endometriosis
Thomas D'Hooghe Editor
Biomarkers for Endometriosis State of the Art
Editor Thomas D'Hooghe Department of Development and Regeneration Organ Systems, Group Biomedical Sciences, KU Leuven (University of Leuven) Leuven, Belgium Global Medical Affairs Fertility Research & Development, Merck KGaA Darmstadt, Hessen, Germany
ISBN 978-3-319-59854-3 ISBN 978-3-319-59856-7 (eBook) DOI 10.1007/978-3-319-59856-7 Library of Congress Control Number: 2017947042 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Biomarkers and Endometriosis: The Need to Move Beyond Innovation to Validation Preface
This book presents a state-of-the-art description on how much progress has been made in the development of a noninvasive test for the diagnosis of endometriosis. Such a test is much needed, especially for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility without evidence of endometriotic cysts, nodules, or adhesions on gynecological ultrasound. This would include nearly all cases with only peritoneal endometriosis, some cases of moderate–severe endometriosis without a clearly visible ovarian endometrioma, and cases with pelvic adhesions and/or other pelvic pathology undetectable by gynecological ultrasound. Ideally, this test could also substitute gynecological ultrasound and allow the diagnosis of endometriosis in areas where ultrasound is not available or reliable. The main aim of such a test would be not to miss any woman who might benefit from endometriosis surgery to improve pelvic pain an
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