Biomatrices for Heart Regeneration and Cardiac Tissue Modelling In Vitro
Cardiac muscle is the hardest working muscle in the body, pumping approximately 70 g of blood with every heartbeat, circulating 9500 l of blood daily and contracting over 3 billion times during the average human’s life. Heart failure – a heterogeneous syn
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Biomatrices for Heart Regeneration and Cardiac Tissue Modelling In Vitro I. Kulvinskiene, R. Aldonyte, R. Miksiunas, A. Mobasheri, and Daiva Bironaite
Abstract
Cardiac muscle is the hardest working muscle in the body, pumping approximately 70 g of blood with every heartbeat, circulating 9500 l of blood daily and contracting over 3 billion times during the average human’s life. Heart failure – a heterogeneous syndrome – is a major and increasing health care problem worldwide and a leading cause of hospitalization and morbidity in elderly. Adequate heart tissue regeneration in human is lacking. Challenges to engineer heart tissue and employ it in vitro or in regenerative medicine remain to be solved. First of all, cardiac tissue bioengineering requires robust and powerful cells capable of differentiating into I. Kulvinskiene, R. Aldonyte, R. Miksiunas, and D. Bironaite (*) Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania e-mail: [email protected]; [email protected] A. Mobasheri Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
cardiomyogenic lineages in combination with effective, safe and highly specialized biomaterials, hydrogels and/or scaffolds for recreating the native extracellular microenvironment. Advances in stem cell and biomaterial science already provided an increasing array of cell resources, their cultivation technologies and biomatrices for efficient and safe cardiac tissue reconstruction. In order to develop new cardiac tissue mimicking technologies in vitro, it is necessary to analyze the advantages and drawbacks of already established biosystems. Therefore, in this paper, we provide a comprehensive overview of recently employed cells, 2D and 3D biomatrices for cardiac tissue engineering and review the current state-of-the-art in this field as well as future directions. Keywords
Biomaterials · Biomatrices · Cardiac muscle · Regenerative medicine · Remodeling · Tissue engineering
Abbreviations
Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine University of Oulu, Oulu, Finland
ADSC AuNRs
Department of Orthopedics and Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
BMP4 CDC
adipose tissue-derived stem cells albumin electrospun fibers and gold nanorods bone morphogenetic protein 4 cardiosphere-derived cells
I. Kulvinskiene et al.
CM CNT CPCs CPS CVD EBs ECM ESCs GAG G-CSF GSK3 HF hFFs HGF IC IGF-1 IM iPSC LVEF MEF MRI MSC Nrg PCL PCL PDGFRα PFHy PGA pHLIP PIPAAm PLA PSC RCVI Sca 1 SDF-1 TESI TGF-β VEGF
1
cardiomyocytes carbon nanotubes cardiac progenitor cells cardio progenitor spheres cardiovascular diseases embryonic bodies extracellular matrix embryonic stem cells glycosaminoglycan granulocyte colony-stimulating factor glycogen synthase kinase 3 heart failure human foreskin fibroblasts hepatocyte growth factor intracoronary infusion insulin-like growth factor
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