Stem Cells and Cardiac Regeneration
This book provides an update of recent advances in the basic and clinical applications of cell-based therapies for myocardial repair and regeneration in ischemic heart disease (IHD) and heart failure (HF). The first sections of the book illuminate basic a
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Rosalinda Madonna Editor
Stem Cells and Cardiac Regeneration
Stem Cell Biology and Regenerative Medicine
Series Editor Kursad Turksen, Ph.D. [email protected]
More information about this series at http://www.springer.com/series/7896
Rosalinda Madonna Editor
Stem Cells and Cardiac Regeneration
Editor Rosalinda Madonna Institute of Cardiology Department of Neurosciences and Imaging Laboratory of Experimental Cardiology Center of Excellence on Aging—CESI “G. d’Annunzio” University Chieti Scalo, Italy
ISSN 2196-8985 ISSN 2196-8993 (electronic) Stem Cell Biology and Regenerative Medicine ISBN 978-3-319-25425-8 ISBN 978-3-319-25427-2 (eBook) DOI 10.1007/978-3-319-25427-2 Library of Congress Control Number: 2015958809 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
To our families and to our coworkers—our extended families
Preface
Ischemic heart disease (IHD) and heart failure (HF) are the major causes of morbidity and mortality in Europe and worldwide. IHD and HF patients could benefit from therapies that would accelerate natural processes of postnatal collateral vessel formation and/or muscle regeneration. Although treatment for acute myocardial infarction has improved over the past decades, there are currently no effective therapies for the associated problem of IHD and HF. Therefore, novel therapeutic strategies are required in order to reduce the extent of myocardial infarction, preserve cardiac function, and improve clinical outcomes in patients with IHD. The purpose of this book is to provide an update of recent advances in the basic and clinical applications of cell-based therapies for myocardial repair and regeneration in IHD and HF. In this book, cardiologist clinicians and scientists will have an opportunity to lear
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