Brain 18 F-FDG distribution: which region is most affected by increased plasma glucose levels?
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LETTER TO THE EDITOR
Brain 18F-FDG distribution: which region is most affected by increased plasma glucose levels? Kenji Ishibashi1 · Masashi Kameyama1,2 · Kenji Ishii1 · J-ADNI Study Group Received: 12 December 2018 / Accepted: 18 December 2018 © The Japanese Society of Nuclear Medicine 2019
Keywords 18F-FDG · Positron emission tomography · Glucose Dear Sir, Both similarities and differences can be found between the Alzheimer’s Disease Neuroimaging Initiative studies in North America (ADNI) and Japan (J-ADNI) as recently shown by Iwatsubo and colleagues [1]. Here, we present an example of the difference in 18F-FDG data between the two multicenter studies. Our series of studies has shown that increased plasma glucose levels can alter the brain 18F-FDG distribution pattern from normal to Alzheimer’s disease (AD) like [2]. Apostolova and colleagues recently confirmed this phenomenon using 18F-FDG images of normal subjects (n = 87, The data used for this research were originally obtained by the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI) led by Prof. Takeshi Iwatsubo and available at the website of the National Bioscience Database Center (NBDC)/the Japan Science and Technology Agency (JST). J-ADNI Study Group provided data but did not participate in the analysis or writing of this research. A complete listing of J-ADNI investigators can be found at: https://humandbs.biosciencedbc.jp/en/hum0043-j-adni-authors. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12149-018-01327-4) contains supplementary material, which is available to authorized users. * Kenji Ishibashi [email protected] Masashi Kameyama kame‑[email protected] Kenji Ishii [email protected] 1
Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35‑2 Sakae‑cho, Itabashi‑ku, Tokyo 173‑0015, Japan
Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
2
74.2 ± 5.3 years) from the ADNI study [3]. Additionally, they observed that the occipital cortex was one of the preferential areas where increased plasma glucose levels decreased 18 F-FDG uptake. However, this occipital cortex change was not detected in our series of studies [2] or other relevant studies [4]. Therefore, we are concerned about the detection of the occipital cortex in the study by Apostolova and colleagues using the ADNI data [3]. To address this concern, we obtained a large sample of normal 18F-FDG images from the J-ADNI study (https://humandbs.biosciencedbc.jp/ en/hum0043-v1), and examined whether increased plasma glucose levels can preferentially decrease 18F-FDG uptake in the occipital cortex. Ninety-three normal subjects (67.7 ± 5.7 years) were enrolled, and divided into two groups according to plasma glucose levels: a normal group (n = 64, ≥ 80 ~
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