Cancer and Zebrafish Mechanisms, Techniques, and Models
This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncog
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David M. Langenau Editor
Cancer and Zebrafish Mechanisms, Techniques, and Models
Advances in Experimental Medicine and Biology Volume 916 Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy
More information about this series at http://www.springer.com/series/5584
David M. Langenau Editor
Cancer and Zebrafish Mechanisms, Techniques, and Models
Editor David M. Langenau Molecular Pathology and Cancer Center Massachusetts General Hospital Charlestown, MA, USA
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-319-30652-0 ISBN 978-3-319-30654-4 (eBook) DOI 10.1007/978-3-319-30654-4 Library of Congress Control Number: 2016934705 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Prelude: Cancer and Zebrafish
Cancer and Its History Cancer is the second leading cause of death in the United States after heart disease and claimed the lives of approximately 585,000 Americans in 2014. In total, nearly 1.7 million people will be diagnosed with cancer in the United States this year and approximately 14.1 million worldwide. Although cancer rates increase with advanced age, many cancers arise in children, adolescents, and young adults. Moreover, distinct cancer subtypes are uniquely found within specific age classes, ethnicity, gender, and regions of the world—avowing that cancer can touch the life of anyone. Cancer arises when cells within the body acquire uncontrolled growth. Cancer is not a single disease, but rather a heterogeneous compilation of diseases that are defined by the anatomical location
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