Murine Models, Energy Balance, and Cancer
This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interes
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For further volumes: http://www.springer.com/series/8282
Nathan A. Berger Editor
Murine Models, Energy Balance, and Cancer
2123
Editor Nathan A. Berger Center for Science, Health & Society Case Western Reserve University School of Medicine Cleveland, Ohio USA
ISSN 2199-2622 ISSN 2199-2630 (electronic) Energy Balance and Cancer ISBN 978-3-319-16732-9 ISBN 978-3-319-16733-6 (eBook) DOI 10.1007/978-3-319-16733-6 Library of Congress Control Number: 2015940548 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface
Overweight and obesity have increased on a worldwide basis, reaching 60–70 % of the adult population in developed countries and the incidence continues to increase in developing countries. In addition to having devastating psychosocial impact and causing severe debilitation and death at the individual level, this obesity pandemic along with an associated increase in multiple malignancies poses a major series of public health problems that challenge both health care systems and health care costs. Cohort and case control studies in humans have contributed significantly to understanding the epidemiology and clinical correlates of these problems. Likewise, great insights have been gained from biochemical, molecular biologic, genetic, physiologic, and pathologic analysis of human tissues and fluids, and in some cases, it has been possible to conduct randomized controlled trials in humans to study cause and control. The latter, however, have usually been short-term relative to the long-term problems of obesity development and control and its relation to cancer. Moreover, obesity and its comorbidities have been difficult to study in humans due to difficulties in sustaining controlled diets, environments, and behavior
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