Cancer Nanotechnology Methods and Protocols
Early detection of cancer at the cellular level, even before anatomic anomalies are visible, is critical to more efficacious and cost effective diagnosis and therapeutic advances. In Cancer Nanotechnology: Methods and Protocols, an international panel of
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MO L E C U L A R BI O L O G Y
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
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Cancer Nanotechnology Methods and Protocols
Edited by
Stephen R. Grobmyer and Brij M. Moudgil University of Florida, Gainesville, FL, USA
Editors Stephen R. Grobmyer Division of Surgical Oncology Department of Surgery University of Florida PO Box 100286 Gainesville FL 32610 USA [email protected]
Brij M. Moudgil Department of Materials Science and Engineering Particle Engineering Research Center University of Florida P.O.Box 116005 Gainesville FL 32611 USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-608-5 e-ISBN 978-1-60761-609-2 DOI 10.1007/978-1-60761-609-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010920087 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover illustration: Digitally modified transmission electron micrograph of ca. 50 nm multifunctional gold speckled silica (GSS) nanoparticle. Synthesized using microemulsions, GSS nanoparticles can be engineered and utilized as the mediators of cancer theranostics (Chapter 5). Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Cancer nanotechnology is a rapidly emerging field which holds great promise for revolutionizing cancer detection, diagnosis, treatment, and cure. Furthermore, cancer nanotechnology holds the potential to ultimately improve access to cancer care worldwide. Early detection of cancer at the cellular level, even before anatomic anomalies are visible, is critical to more efficacious and cost-effective diagnosis and therapeutic advances. Non-invasive techniques are required that are capable of reliably imaging at the molecular scale – 100–1,000 cells as opposed to the current techniques that r
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