Cancer Cytogenetics Methods and Protocols
This volume provides readers with detailed protocols covering the main cancer cytogenetics techniques needed for clinical utilization and research purposes. The chapters in this book cover topics such as chromosome preparation for myeloid malignancies; ch
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Thomas S.K. Wan Editor
Cancer Cytogenetics Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cancer Cytogenetics Methods and Protocols
Edited by
Thomas S.K. Wan Haematology Division, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
Editor Thomas S.K. Wan Haematology Division Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Prince of Wales Hospital Shatin, Hong Kong, China
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6701-8 ISBN 978-1-4939-6703-2 (eBook) DOI 10.1007/978-1-4939-6703-2 Library of Congress Control Number: 2016958568 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The discovery of the Philadelphia chromosome in 1960 ushered the field of cancer cytogenetics study into a new era. The development of fluorescence in situ hybridization (FISH) in 1980 helped to overcome many of the drawbacks in the assessment of genetic alterations in cancer cells by karyotyping. Subsequent methodological advances in molecular cytogenetics that were initiated in the early 1990s based on the principle of FISH have greatly enhanced the efficiency and accuracy of karyotype analysis by marrying conventional cytogenetics with molecular technologies. All of these molecular cytogenetic techniques add colors to the monotonous world of conventional chromosome banding. Currently, both karyotyping and FISH studies have emerged as indispensable tools for both
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