Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology
The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there
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Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology
Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology
Sadegh Babashah Editor
Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology
Editor Sadegh Babashah Department of Molecular Genetics Faculty of Biological Sciences Tarbiat Modares University Tehran, Iran
ISBN 978-3-319-21029-2 ISBN 978-3-319-21030-8 DOI 10.1007/978-3-319-21030-8
(eBook)
Library of Congress Control Number: 2015950061 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
I would like to dedicate this book to my dear wife for her patience, intellect and adventurous spirit. Her continued support and ongoing encouragement were great sources of inspiration when I spent time working on this project. I also dedicate this book to my invaluable teachers and advisors Prof. Majid Sadeghizadeh and Prof. Sirous Zeinali, the pioneers of molecular biology and medicine in Iran. And finally, I dedicate this book to those who pursue their dreams with passion and determination despite the many daunting hurdles and pressures they face.
Preface
The CSC theory posits tumor development might arise from a rare population of cells that show the stem cell-like properties. This theory was initially formulated approximately 150 years ago. The recent decade studies have tremendously advanced our understanding of the molecular pathogenesis of cancer. CSCs have been demonstrated to underlie resistance to conventional chemotherapeutics resulting in tumor recurrence and poor prognosis. In this context, the need to develop novel approaches for eradicating CSCs in order to inhibit tumor recurrence is considered as a major challenge in cancer treatm
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