Cellular Therapy for Stroke and CNS Injuries

The first book to focus on cellular therapy for stroke and other CNS injuries. Addresses recent research on all relevant cell types including neural stem cells, bone marrow stem cells, endothelial progenitor cells, and many others that have had protective

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Series Editor John Zhang Neurosurgery, Physiology, Loma Linda University, Loma Linda, USA

The Springer Series in Translational Stroke Research will cover basic, translational and clinical research, emphasizing novel approaches to help translate scientific discoveries from basic stroke research into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma. More information about this series at http://www.springer.com/series/10064

Li-Ru Zhao • John H. Zhang Editors

Cellular Therapy for Stroke and CNS Injuries

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Editors Li-Ru Zhao Department of Neurosurgery SUNY Upstate Medical College Syracuse New York USA

John H. Zhang Loma Linda University School of Medicine Depts of Physiology Loma Linda California USA

ISBN 978-3-319-11480-4    ISBN 978-3-319-11481-1 (eBook) DOI 10.1007/978-3-319-11481-1 Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014955546 © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

The Preface

Stroke and injuries in the central nervous system (CNS) such as traumatic brain injury and spinal cord injury are the leading causes of long-term