Depot-specific regulation of autotaxin with obesity in human adipose tissue
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ORIGINAL PAPER
Depot-specific regulation of autotaxin with obesity in human adipose tissue Chloé Rancoule & Rodolphe Dusaulcy & Karine Tréguer & Sandra Grès & Charlotte Guigné & Didier Quilliot & Philippe Valet & Jean Sébastien Saulnier-Blache
Received: 4 January 2012 / Accepted: 16 May 2012 / Published online: 27 May 2012 # University of Navarra 2012
Abstract Autotaxin (ATX) is a lysophospholipase D involved in synthesis of a bioactive mediator: lysophosphatidic. ATX is abundantly produced by adipocytes and exerts a negative action on adipose tissue expansion. In both mice and humans, ATX expression increases with obesity in association with insulin resistance. In the present study, fat depot-specific regulation of ATX was explored in human. ATX mRNA expression was quantified in visceral and subcutaneous adipose tissue in obese (BMI>40 kg/m2; n027) and nonobese patients (BMI 40 kg/m2; n 027)
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before a bariatric surgery. Subcutaneous (n04) and visceral fat (n010) were also collected from non-obese patients (BMI
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