Chemogenomics and Chemical Genetics A User's Introduction for Biolog
Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry.
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Grenoble Sciences The aims of Grenoble Sciences are double: ! to produce works corresponding to a clearly defined project, without the constraints of trends or programme, ! to ensure the utmost scientific and pedagogic quality of the selected works: each project is selected by Grenoble Sciences with the help of anonymous referees. Next, the authors work for a year (on average) with the members of an interactive reading committee, whose names figure in the front pages of the work, which is then co-published with the most suitable publishing partner. Contact: Tel.: (33) 4 76 51 46 95 - E-mail: [email protected] website: http://grenoble-sciences.ujf-grenoble.fr Scientific Director of Grenoble Sciences: Jean BORNAREL, Emeritus Professor at Joseph Fourier University, Grenoble, France Grenoble Sciences is a department of Joseph Fourier University, supported by the French National Ministry for Higher Education and Research and the Rhône-Alpes Region.
Chemogenomics and Chemical Genetics is an improved version of the original book Chemogénomique - Des petites molécules pour explorer le vivant sous la direction de Eric MARÉCHAL, Sylvaine ROY et Laurence LAFANECHÈRE, EDP Sciences - Collection Grenoble Sciences, 2007, ISBN 978 2 7598 0005 6. The Reading Committee of the French version included the following members: ! Jean DUCHAINE, Principal Advisor of the Screening Platform, Institute for Research in Immunology and Cancer, University of Montreal, Canada ! Yann GAUDUEL, Director of Research at INSERM, Laboratory of Applied Optics (CNRS), Ecole Polytechnique, Palaiseau, France ! Nicole MOREAU, Professor at the Ecole Nationale Supérieure de Chimie, Pierre and Marie Curie University, Paris, France ! Christophe RIBUOT, Professor of Pharmacology at the Faculty of Pharmacy, Joseph Fourier University, Grenoble, France
Translation performed by Philip SIMISTER
Typesetted by Centre technique Grenoble Sciences Cover illustration: Alice GIRAUD
(with extracts from a DNA microarray image - Biochip Laboratory/Life Sciences Division/CEA - and a photograph of actin filaments array and adhesion plates in a mouse embryonic cell - Yasmina SAOUDI, INSERM U836 Grenoble, France)
Eric Maréchal • Sylvaine Roy • Laurence Lafanechère Editors
Chemogenomics and Chemical Genetics A User’s Introduction for Biologists, Chemists and Informaticians
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Editors Dr. Eric Maréchal Laboratory of Plant Cell Physiology UMR 5168, CNRS-CEA-INRAJoseph Fourier University Rue des Martyrs 17 38054 Grenoble Cedex 9 France [email protected]
Sylvaine Roy Laboratory of Plant Cell Physiology UMR 5168, CNRS-CEA-INRAJoseph Fourier University Rue des Martyrs 17 38054 Grenoble Cedex 9 France [email protected]
Laurence Lafanechère Albert Bonniot Institute Department of Cellular Differentiation and Transformation Rond-point de la Chantourne 38706 La Tronche Cedex France [email protected]
Translator: Philip Simister Weatherall Institute of Molecular Medicine University of Oxford Oxford OX3 9DS, UK
Originally published in French:
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