Death Receptors and Cognate Ligands in Cancer
Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors th
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Series Editors Dietmar Richter, Henri Tiedge
Holger Kalthoff (ed.)
Death Receptors and Cognate Ligands in Cancer
Editor Holger Kalthoff Sektion für Molekulare Onkologie Institut für Experimentelle Tumorforschung Krebszentrum Nord - CCC UK S-H, Campus Kiel Arnold-Heller-Strasse 3 (Haus 18) 24105 Kiel Germany [email protected]
Series Editors Dietmar Richter Center for Molecular Neurobiology University Medical Center HamburgEppendorf (UKE) University of Hamburg Martinistrasse 52 20246 Hamburg Germany [email protected]
Henri Tiedge The Robert F. Furchgott Center for Neural and Behavioral Science Department of Physiology and Pharmacology Department of Neurology SUNY Health Science Center at Brooklyn Brooklyn, New York 11203 USA [email protected]
ISBN 978-3-642-03044-4 e-ISBN 978-3-642-03045-1 DOI 10.1007/978-3-642-03045-1 Springer Heidelberg Dordrecht London New York Results and Problems in Cell Differentiation ISSN 0080-1844 Library of Congress Control Number: 2009932686 © Springer-Verlag Berlin Heidelberg 2009 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable for prosecution under the German Copyright Law. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: WMXDesign GmbH, Heidelberg Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
The Role of TNF in Cancer..................................................................... Harald Wajant Many Checkpoints on the Road to Cell Death: Regulation of Fas–FasL Interactions and Fas Signaling in Peripheral Immune Responses............................................................ Madhu Ramaswamy, Sophia Y. Cleland, Anthony C. Cruz, and Richard M. Siegel FasL Expression and Reverse Signalling................................................ M. Lettau, M. Paulsen, D. Kabelitz and O. Janssen Impact of TNF-R1 and CD95 Internalization on Apoptotic and Antiapoptotic Signaling............................................. Stefan Schütze and Wulf Schneider-Brachert Ubiquitination and TNFR1 Signaling..................................................... Ken-ichi Fujita and Srinivasa M. Srinivasula
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From Biochemical Principles of Apoptosis Induction by TRAIL to Application in Tumour Therapy.................... 115 Stefanie M. Cordier, Kerstin Papenfuss, and Henning Walczak Therapeutic Targeting of
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