Chemokines and Viral Infection
This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the
- PDF / 2,142,334 Bytes
- 162 Pages / 439.378 x 666.252 pts Page_size
- 107 Downloads / 219 Views
Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California · H. Wagner, Munich
T.E. Lane (Ed.)
Chemokines and Viral Infection With 14 Figures and 7 Tables
123
Thomas E. Lane, Ph.D. Associate Professor Department of Molecular Biology and Biochemistry Center for Immunology 3205 McGaugh Hall University of California, Irvine Irvine, CA 92697-3900 USA e-mail: [email protected] Cover Illustration by Thomas E. Lane (this volume) Chemokines and MHV-induced demyelination (see Fig. 2 of the first chapter)
Library of Congress Catalog Number 72-152360 ISSN 0070-217X ISBN-10 3-540-29207-1 Springer Berlin Heidelberg New York ISBN-13 978-3-540-29207-4 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springeronline.com © Springer-Verlag Berlin Heidelberg 2006 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Simon Rallison, Heidelberg Desk editor: Anne Clauss, Heidelberg Production editor: Nadja Kroke, Leipzig Cover design: design & production GmbH, Heidelberg Typesetting: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig Printed on acid-free paper SPIN 11559986 27/3150/YL – 5 4 3 2 1 0
Preface
Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G proteincoupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression might be integral in leukocyte recruitment to inflamed tissue [1–3]. Within a relatively short period of time, early participants within the field determined that these proteins displayed distinct and conserved structural features and exerted potent chemotactic effects on
Data Loading...
