Chloroquine diphosphate
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Therapeutic failure: 7 case reports In a study involving 36 patients with acute Plasmodium vivax malaria, conducted between November 2001 and March 2002 in Indonesia, 7 patients [ages and sexes not stated] were described, who exhibited therapeutic failure during treatment with chloroquine diphosphate for the Plasmodium vivax malaria. The patients with Plasmodium vivax mono-infection, started receiving treatment with chloroquine diphosphate [Chloroquine phosphate; Resochin] uncoated tablets for 3 days (25mg base/kg: 10 mg/kg on day 0 and day 1, and 5 mg/kg on day 2) [routes not stated]. However, on day 2, one patient showed higher parasite count indicating treatment failure. The patient’s parasite count was noted as 5240 /µL on day 0 and 6320 /µL on day 2. On day 3, similar parasite count was noted in two patients indicating treatment failure. The parasite count was 1120 /µL (on day 0) and 1040 /µL (on day 3) in one patient, and 8960 /µL (on day 0) and 11000 /µL (on day 3) in the other patient. On day 7, two more patients, who initially showed reduction in parasite count, showed persistent parasite count on day 7 indicating treatment failure. The parasite count was 9240 /µL (on day 0) and 40 /µL (on day 7) in one patient, and 9440 /µL (on day 0) and 80 /µL (on day 7) in the other patient. Recurrence after initial clearance of asexual parasitemias were noted in two more patients on day 14 and on day 28 indicating treatment failure. No detectable drug level in blood was noted in the patient who recurred on day 14 despite having normal drug level in blood on day 3 (625 ng/mL). Both the patients, who showed recurrence of asexual parasitemias, were treated after removal from the analysis. Sutanto I, et al. Resistance to chloroquine by Plasmodium vivax at Alor in the Lesser Sundas Archipelago in eastern Indonesia. American Journal of Tropical Medicine and 803518791 Hygiene 81: 338-342, No. 2, Aug 2009. Available from: URL: http://doi.org/10.4269/ajtmh.2009.81.338
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Reactions 5 Dec 2020 No. 1833
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