Chromatographic/Chromatographic Spectroscopic Combination Methods for the Analysis of Botanical Drugs
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Chromatographic/Chromatographic Spectroscopic Combination Methods for the Analysis of Botanical Drugs A. Douglas Kinghorn and Eun-Kyoung Yuny Drug Information Journal 1998 32: 487 DOI: 10.1177/009286159803200221 The online version of this article can be found at: http://dij.sagepub.com/content/32/2/487
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Drug Information Journal. Vol. 32. pp. 487495, I998
0092-8615/98
Printed in the USA. All rights reserved.
Copyright 0 1998 Drug Information Association Inc.
CHROMATOGRAPHIC/ CHROMATOGRAPHIC SPECTROSCOPIC COMBINATION METHODS FOR THE ANALYSIS OF BOTANICAL DRUGS A. DOUGLAS KINGHORN, PHD, DSc Professor, Associate DirectodAssistant Head
EUN-KYOUNG (YUNY)
SEO,
MS
Graduate Student Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois
Bioactive plant secondary metabolites tend to occur in complex mixtures in botanical drugs (phytophamceuticals), and the design of procedures for the analysis of such compounds requires a thorough understanding of the phytochemistry involved and considerable ingenuity on the part of the analyst. Several published chromatographic and chromatographic/spectroscopicanalytical methods for three botanical products of commercial importance are reviewed, namely, those from Gingko biloba, Croton tiglium, and Stevia rebaudiana. Key Words:Analysis; Chromatography; Combined chromatographylspectroscopy;Botanical drugs; Phytophaxmaceuticals
INTRODUCTION THERE IS A BROAD AND increasing interest in the development of analytical methods for plant secondary metabolites from crude plant material in the agrochemical, food, pharmaceutical, and other industries. The design of these methods typically necessitates considerations of extraction, solvent partitioning, purification, identification, and quantification procedures. Chromatographic meth-
Based on a presentation at the DIA Workshop “Botanical Quality: Characterization and Identification.” April 9-10, 1996, Washington, District of Columbia. Reprint address: A. Douglas Kinghorn, PhD, DSc, Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois at Chicago (WC 877). 833 South Wood Street, Chicago, IL 60612.
ods, in particular high-performance liquid chromatography (HPLC), are used extensively for plant natural product purification, and while certain biochemical, chemical, electrometric, and radiometric procedures may be e
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