Clinical effects of curcumin in enhancing cancer therapy: A systematic review
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RESEARCH ARTICLE
Open Access
Clinical effects of curcumin in enhancing cancer therapy: A systematic review Kamran Mansouri1, Shna Rasoulpoor2, Alireza Daneshkhah3, Soroush Abolfathi4, Nader Salari5,6* , Masoud Mohammadi7*, Shabnam Rasoulpoor8 and Shervin Shabani9
Abstract Background: Curcumin is herbal compound that has been shown to have anti-cancer effects in pre-clinical and clinical studies. The anti-cancer effects of curcumin include inhibiting the carcinogenesis, inhibiting angiogenesis, and inhibiting tumour growth. This study aims to determine the Clinical effects of curcumin in different types of cancers using systematic review approach. Methods: A systematic review methodology is adopted for undertaking detailed analysis of the effects of curcumin in cancer therapy. The results presented in this paper is an outcome of extracting the findings of the studies selected from the articles published in international databases including SID, MagIran, IranMedex, IranDoc, Google Scholar, ScienceDirect, Scopus, PubMed and Web of Science (ISI). These databases were thoroughly searched, and the relevant publications were selected based on the plausible keywords, in accordance with the study aims, as follows: prevalence, curcumin, clinical features, cancer. Results: The results are derived based on several clinical studies on curcumin consumption with chemotherapy drugs, highlighting that curcumin increases the effectiveness of chemotherapy and radiotherapy which results in improving patient’s survival time, and increasing the expression of anti-metastatic proteins along with reducing their side effects. Conclusion: The comprehensive systematic review presented in this paper confirms that curcumin reduces the side effects of chemotherapy or radiotherapy, resulting in improving patients’ quality of life. A number of studies reported that, curcumin has increased patient survival time and decreased tumor markers’ level. Keywords: Prevalence, Curcumin, Clinical feature, Cancer, Systematic review
Background Research over the past 25 years has significantly increased our understanding of the molecular genetic basis of cancer. It is now well known that cancer is caused by a set of molecular genetic changes that lead to loss of growth control and cellular differentiation, resulting in
* Correspondence: [email protected]; [email protected] 5 Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran 7 Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran Full list of author information is available at the end of the article
uncontrollable cell growth that eventually leads to tumor formation [1]. More than half of all cancers occur in developing countries including those located in Southern America and Asia. Nearly three-quarters of people of these countries are classified into low or middle-income categories. The cancer survival rates in developing countries are generally one-third of the patients i
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