Clinical Epigenetics
In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human di
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nical Epigenetics
Clinical Epigenetics
Luke B. Hesson • Antonia L. Pritchard Editors
Clinical Epigenetics
Editors Luke B. Hesson Faculty of Medicine UNSW NSW, NSW, Australia
Antonia L. Pritchard Oncogenomics QIMR Berghofer Medical Research Institute Brisbane, QLD, Australia
ISBN 978-981-13-8957-3 ISBN 978-981-13-8958-0 https://doi.org/10.1007/978-981-13-8958-0
(eBook)
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Preface
The purpose of this book Clinical Epigenetics is threefold: (1) to introduce epigenetics to a non-expert scientific audience, (2) to describe current and future clinical utility of epigenetics, and (3) to help professionals (scientists and clinicians) to understand, in a practical sense, how epigenetics is relevant in a clinical context. In the discipline of genetic pathology, genetic testing informs the clinical management of patients, including their diagnosis. Genetic testing is widely used in a variety of clinical contexts, whereas epigenetics is currently underappreciated and underutilised. This book emphasises the importance of epigenetics in health and disease with the aim of bringing it closer to being more regularly used in diagnostic laboratories. Chapter 1 provides a historical perspective on the origins and development of the field of epigenetics and describes the pivotal research findings of early pioneers. The timeline of major discoveries will be discussed in the context of genetic knowledge at the time. Key terms will be introduced and defined in footnotes to allow uninterrupted flow of the narrative. These have been included to inform and guide the reader through an ever-evolving lexi
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