Epigenetics of Aging
Revealing the molecular basis of aging has been one of the most challenging aspects of medical science, and now the epigenetics of aging is in a Renaissance phase. This seminal work covers the fascinating role of epigenetics in aging, ranging from basic e
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Epigenetics of Aging
Epigenetics of Aging
Trygve O. Tollefsbol Editor
Epigenetics of Aging
123
Editor Trygve O. Tollefsbol Department of Biology University of Alabama at Birmingham 1300 University Blvd. Birmingham, AL 35294-1170 USA [email protected]
ISBN 978-1-4419-0638-0 e-ISBN 978-1-4419-0639-7 DOI 10.1007/978-1-4419-0639-7 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009932905 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Numerous studies have indicated that epigenetic mechanisms may play a major role in both cellular and organismal aging. These epigenetic processes not only include DNA methylation and histone modifications but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this seminal book on aging epigenetics range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process and age-associated disorders. The major topics of aging epigenetics covered in this book are (1) DNA methylation and histone modifications in aging, (2) other epigenetic processes and aging, (3) impact of epigenetics on aging, (4) epigenetics of age-related diseases, (5) epigenetic interventions and aging, and (6) future directions/perspectives in aging epigenetics. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging but also in several types of histone modifications. Many epigenetic aberrations may have an impact on aging processes through control of telomerase, modifications of telomeres, and epigenetic drift. The latter is evident in the rec
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