Clinical outcomes of dialysis patients with COVID-19 in the initial phase of the COVID-19 outbreak in Wuhan, China
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NEPHROLOGY - ORIGINAL PAPER
Clinical outcomes of dialysis patients with COVID‑19 in the initial phase of the COVID‑19 outbreak in Wuhan, China Xingruo Zeng1 · Xiaomei Huang1 · Li Xu1 · Jianwei Xiao2 · Lianqing Gu1 · Yin Wang1 · Yanhong Tuo1 · Xun Fang1 · Wenzhe Wang1 · Ni Li1 · Wei Xiao1 · Yan Yang3 · Pengju Gong3 · Wenjing Song3 · Jingbo Gao3 · Xin He3 · Sirui Huang3 · Yifan Zeng3 · Lei Wei3 · Wenli Chen1 Received: 28 April 2020 / Accepted: 28 September 2020 © Springer Nature B.V. 2020
Abstract Purpose Since the end of 2019, dialysis patients have been at risk of coronavirus disease 2019 (COVID-19) as well as other potential complications. Hence, we sought to describe the clinical characteristics of dialysis patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods We reviewed clinical outcomes, which consisted of clinical data extracted from the medical records of 695 registered dialysis patients at the Dialysis Center of Central Hospital of Wuhan from January 13th, 2020, to February 29th, 2020, and performed statistical analysis. According to the results, there were 447, 227 and 21 hemodialysis (HD), peritoneal dialysis (PD) and combined HD and PD (HD&PD) cases, respectively. Results During the outbreak of COVID-19, 36 dialysis patients were infected by SARS-CoV-2. Among those 36 patients, 32 (7.2%) were on HD, and 4 (1.8%) were on PD. When comparing SARS-CoV-2 infection between HD and PD, the relative risk was 4.07 (RR = 4.07, 95% CI 1.46–11.35). We noted a median age of 66 years during the observation period, and the number of male patients was 23 (63.9%). There were 15 fatal cases tested positive for SARS-CoV-2 (13 cases on HD and 2 cases on PD). By comparing mortality in the same period of 2018, 2019 and 2020, the all-cause mortality of hemodialysis patients was significantly higher in 2020 (4.89%) than in either 2018 (2.55%) or 2019 (1.97%). There was no significant difference in mortality from all causes excluding COVID-19, during the same period among the 3-year period. However, during the COVID-19 outbreak, the mortality from all causes excluding COVID-19 was 2.73%, which was slightly higher than that from COVID-19 (2.16%). Conclusions Although COVID-19 seriously threatens the health of people with uremia, deaths from all causes excluding COVID-19 during the epidemic cannot be ignored. Keywords Hemodialysis · Peritoneal dialysis · COVID-19 · Clinical outcome · Uremia
Introduction
Xingruo Zeng, Xiaomei Huang, and Li Xu have contributed equally. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11255-020-02670-0) contains supplementary material, which is available to authorized users. * Lei Wei [email protected] * Wenli Chen [email protected] Extended author information available on the last page of the article
In late December 2019, atypical pneumonia cases caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started being reported in Wuhan [1]. This novel virus soon spread widely among the city of
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