Cognitive impairment, health-related quality of life and vocational status at early stages of multiple sclerosis: a 7-ye
- PDF / 255,233 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 24 Downloads / 165 Views
ORIGINAL COMMUNICATION
Cognitive impairment, health-related quality of life and vocational status at early stages of multiple sclerosis: a 7-year longitudinal study Aure´lie Ruet • Mathilde Deloire • Delphine Hamel Jean-Christophe Ouallet • Klaus Petry • Bruno Brochet
•
Received: 5 January 2012 / Revised: 4 October 2012 / Accepted: 6 October 2012 / Published online: 19 October 2012 Ó Springer-Verlag Berlin Heidelberg 2012
Abstract The association between cognitive impairment, health-related quality of life (HRQoL) and vocational status has been studied in recent years in cross-sectional studies in multiple sclerosis (MS), but longitudinal data are still lacking. This study assesses this association in a sample of 65 newly diagnosed MS patients followed longitudinally. Each patient underwent a standardised clinical assessment, cognitive tests and the HRQoL SEP-59 questionnaire six months after the MS diagnosis (baseline) and seven years later (y7).Vocational status was also established at baseline and at y7 in MS patients. The HRQoL at baseline was severely reduced in MS patients compared with healthy subjects. The independent predictors for HRQoL composite scores at y7 were the baseline depression score and the memory Z-score. Accordingly, 81.5 % of MS patients worked at baseline and only 54.4 % worked at y7. Among the MS patients who did not work at y7, 72.7 % of them were cognitively impaired, while 27.3 % were unimpaired at baseline. The vocational status at y7 was significantly associated with the baseline IPS Z-score, EDSS and age. Vocational status at y7 and its change over 7 years was significantly associated with cognitive deterioration. IPS or memory dysfunction in the early stages of MS is correlated with a decreased level in health perception, independent of fatigue, depression and physical
A. Ruet D. Hamel K. Petry B. Brochet (&) INSERM U.1049 Neuroinflammation, Imagerie et The´rapie de la Scle´rose en plaques, Universite´ de Bordeaux, Case 78, 146 rue Le´o Saignat, 33076 Bordeaux cedex, France e-mail: [email protected] A. Ruet M. Deloire J.-C. Ouallet B. Brochet CHU de Bordeaux, INSERM-CHU CIC-P 0005, and Services de Neurologie, 33076 Bordeaux, France
123
disability. Cognitive impairment at the diagnosis of MS increases the risk of changing vocational status in MS patients seven years later. Keywords Multiple Sclerosis Information processing speed Cognition Quality of life Work Vocational status
Introduction The goal of health-related quality of life (HRQoL) scales is to provide tools adapted to the evaluation of various dimensions of a given situation, including concerns that are not usually taken into account by standard medical assessment [1]. Many studies have used these scales to assess the perceived health in persons with multiple sclerosis (PwMS) [2]. These studies consistently showed that PwMS have a significant decrease in HRQoL. The key factors for such low HRQoL scores have been studied, and low ratings of HRQoL have been associated with physical disab
Data Loading...
