Colchicine
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Iron deficiency anaemia secondary to gastrointestinal disorder: case report A 60-year-old man developed iron deficiency anaemia secondary to gastrointestinal disorder during treatment with colchicine for the atypical parenchymal pulmonary presentation of familial Mediterranean fever (FMF). The man presented with chest discomfort, dyspnoea with productive cough and intermittent diaphoresis, without fevers for the past one year. His medical history was significant for obstructive sleep apnoea, smoking, obesity, gastrooesophageal reflux and selective IgA deficiency. Upon presentation, he was investigated and was diagnosed with atypical parenchymal pulmonary presentation of FMF. He thus started receiving oral colchicine 0.6mg 2 times daily. Following 18 months of the colchicine therapy, he developed iron deficiency anaemia. Subsequent endoscopy along with biopsies of the stomach, oesophagus, small intestines and colon showed prominent mitotic figures and ring mitoses, consistent with gastrointestinal disorder, which was suspected to be a side-effect of colchicine (colchicine toxicity). The man’s therapy with colchicine was therefore stopped, and he started receiving canakinumab for the FMF [outcome not stated]. Author comment: "After 18 months of therapy, he developed iron deficiency anemia. Endoscopy with biopsies of the esophagus, stomach, small intestines, and colon revealed prominent mitotic figures and ring mitoses consistent with colchicine toxicity." Horbal A, et al. Isolated parenchymal pulmonary presentation of familial Mediterranean fever. Annals of Allergy, Asthma and Immunology 123: 603-604, No. 6, Dec 2019. Available from: URL: http://doi.org/10.1016/j.anai.2019.08.464 803439695 USA
0114-9954/19/1783-0001/$14.95 Adis © 2019 Springer Nature Switzerland AG. All rights reserved
Reactions 14 Dec 2019 No. 1783
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