Combination of Vitamin D Metabolites with Selective Inhibitors of Vitamin D Metabolism
1α,25(OH)2D3exerts antiproliferative, differentiating effects on many cell types, including cancer tissues. In most of its target cells, levels of 1α,25(OH)2D3are regulated by local synthesis via CYP27B and metabolism via CYP24. Rapidly induced by vitamin
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P.M. Schlag, Berlin H.-J. Senn, St. Gallen Associate Editors
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164
Springer-Verlag Berlin Heidelberg GmbH
J. Reichrath · M. Friedrich W. Tilgen (Eds.)
Vitamin D Analogs in Cancer Prevention and Therapy With 135 Figures and 37 Tables
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Dr. Jrg Reichrath Prof. Dr. Wolfgang Tilgen Hautklinik und Poliklinik der Universittskliniken des Saarlandes Kirrberger Str. 66421 Homburg/Saar Dr. Michael Friedrich Frauenklinik des Universittsklinikums der Eberhard-Karls-Universitt Calwerstr. 7 71076 Tbingen Indexed in Current Contents and Index Medicus ISSN 0080-0015 ISBN 978-3-642-62435-3 ISBN 978-3-642-55580-0 (eBook) DOI 10.1007/978-3-642-55580-0 Library of Congress Cataloging-in-Publication Data Vitamin D analogs in cancer prevention and therapy / J. Reichrath, F. Michael, W. Tilgen, eds. p. ; cm. – (Recent results in cancer research, ISSN 0080-0015 ; 164) Includes bibliographical references and index. ISBN 978-3-642-62435-3 (alk. paper) 1. Vitamin D – Derivatives – Therapeutic use – Congresses. 2. Cancer – Chemotherapy – Congresses. 3. Cancer – Prevention – Congresses. I. Reichrath, J. (Jrg), 1962– II. Michael, F. (Friedrich), 1966– III. Tilgen, W. (Wolfgang), 1944– IV. Series. [DNLM: 1. Neoplasms – drug therapy. 2. Neoplasms – prevention & control. 3. Vitamin D – analogs & derivatives. 4. Vitamin D – physiology. 5. Vitamin D – therapeutic use. QZ 267 V835 2003] This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. http://www.springer.de Springer-Verlag Berlin Heidelberg 2003 Originally published by Springer-Verlag Berlin Heidelberg New York in 2003 Softcover reprint of the hardcover 1st edition 2003 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Strtz AG, 97080 Wrzburg, Germany Cover design: design & production GmbH, 69121 Heidelberg, Germany Printed on acid-free paper
21/3150/ag – 5 4 3 2 1 0
Contents
1 Molecular Biology of Vitamin D Evolution and Function of Vitamin D .
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