Conductive fabric patch with controllable porous structure and elastic properties for tissue engineering applications
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Conductive fabric patch with controllable porous structure and elastic properties for tissue engineering applications Yuxiang Yin1, Jinhua Mo1, and Jianyong Feng1,* 1
College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
Received: 29 May 2020
ABSTRACT
Accepted: 30 August 2020
Cardiovascular disease has gradually become a kind of lifestyle disease in modern society, and the construction of an engineered cardiac patch (ECP) through tissue engineering means is a promising treatment for myocardial infarction in clinical practice. In this study, polyamide fabric was used as scaffold material. Hydrochloric acid, aniline (AN), and ammonium persulfate (APS) were used as main modification reagents. The knitted ECP was constructed by straight in situ polymerization. Respectively, by using a single variable method to change the concentration of APS and base fabric knit method, through a series of tests analyzing the effect of APS concentration and knitting methods on ECP properties, the optimal preparation of ECP was summarized: under the experimental conditions of hydrochloric acid, AN, and APS solution concentrations of 0.7 mol L-1, the ECP showed the best performance for potential cardiac therapy application: the conductivity can reach 2.63–2.79 S m-1, porosity is 60–62%, average pore size is in the range of 16.4–21.65 lm, and elongation is up to 181.43%, showing superior properties of textiles cardiac patch.
Published online: 22 September 2020
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Introduction Myocardial infarction (MI) has become the leading cause of death for patients with cardiovascular diseases worldwide (especially economically developed regions) [1]. And, over the past few decades, the treatment of cardiac disease has been continuously
developed [2]. However, until now, heart transplantation is still the only sure way to treat end-stage heart failure [3] which can be caused by MI [4] and there are always lots of limitations [5] to having someone else provide a heart donor, such as heart donor deficiency, high infection rate, immunosuppression, and high tumor growth likelihood.
Handling Editor: Chris Cornelius.
Address correspondence to E-mail: [email protected]
https://doi.org/10.1007/s10853-020-05219-9
J Mater Sci (2020) 55:17120–17133
Therefore, it is an urgent need to develop new therapies for MI. Among many potential therapy methods, many researchers impose great hope upon using stem cell transplantation to treat cardiovascular diseases and consider it a likely mainstream therapy in the future, while lack of effective carriers will affect stem cell’s survival and spread [6]. And as early as 1993, Langer and Vacanti [7] had pointed out that tissue engineering would be a good treatment for human tissue repair. Till now, tissue engineering has been applied to repair various tissues, like bone tissue, nerve tissue, and skin tissue [8]. Engineered electrical cardiac patch, as a new product for cardiac disease and can be consider
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