Correction to: Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) induce epigenetic alterations and prom
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CORRECTION
Correction to: Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) induce epigenetic alterations and promote human breast cell carcinogenesis in vitro Paula Pierozan1 · Daiane Cattani1 · Oskar Karlsson1
© The Author(s) 2020
Correction to: Archives of Toxicology https://doi.org/10.1007/s00204-020-02848-6
The correct Fig. 2 is given in this correction. The original article has been updated.
In the original publication of the article, Fig. 2 has been published with an error. An error bar has been introduced in Fig. 2 (panel B, second image to the right).
The original article can be found online at https://doi.org/10.1007/ s00204-020-02848-6. * Paula Pierozan [email protected] 1
Science for Life Laboratory, Department of Environmental Sciences, Stockholm University, 114 18 Stockholm, Sweden
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Vol.:(0123456789)
Archives of Toxicology
2×10 4 0
5×10
CDK6 integrated intensity
Cyclin D1 DAPI Actin
2
p21 integrated intensity
p53 integrated intensity
Fig. 2 Effects on regulatory cell-cycle proteins in daughter cells (D1 and D2) of MCF-10A cells exposed to PFOS (10 μM) or PFOA (100 μM). Representative images of D1 (a) and D2 (b) cells immunostained with Cyclin D1 and actin, CDK6, CDK4, p27, p21 and p53. Integrated fluorescence intensity (c–d and g–p) and nuclear
13
3×10 2×10
5
0
Control
PFOS
PFOA
Control
PFOS
PFOA
8×10 4 6×10 4 4×10 4 2×10
4
0
Control
PFOS
PFOA
1×10 5 8×10 4 6×10 4
***
4×10 4
**
2×10 4 0
o
p21 DAPI
p53 DAPI
1×10 5
5
Control
PFOS
PFOA
2.5×10 5 2×10
5
*
1.5×10 5 1×10 5 5×10 4 0
2×10 4 0
Control
PFOS
PFOA
Control
2×10 3
PFOS
PFOA
*
**
PFOS
PFOA
1.5×10 3 1×10 3 5×10 2 0
h
2×10 5
0
f
*
4×10 4
PFOA
3×10 5
m
p27 DAPI
PFOS
1×10 5
p27 integrated intensity
CDK4 DAPI
Control
4×10 5
k
CDK6 DAPI
*
5×10 5
CDK4 integrated intensity
b
**
1×10 3
i
p53 DAPI
PFOA
***
6×10 4
2×10 4
0
l
p
*
4×10 4
j
n
Control
6×10 4
CDK6 integrated intensity
Nuclear Cyclin D1
1.5×10 3
g
p21 DAPI
PFOS
2×10 3
0
p27 DAPI
Control
Cyclin D1 integrated intensity
4×10 4
e
CDK4 DAPI
*
6×10 4
CDK4 integrated intensity
CDK6 DAPI
**
8×10 4
D2
8×10 4
p27 integrated intensity
Cyclin D1 DAPI Actin
d
D1
1×10 5
Nuclear Cyclin D1
c
PFOA
p21 integrated intensity
PFOS
p53 integrated intensity
Control
Cyclin D1 integrated intensity
a
Control
PFOS
Control
PFOS
PFOA
5×10 5 4×10 5 3×10 5 2×10 5 1×10 5 0
PFOA
8×10 4 6×10 4
*
4×10 4 2×10
4
0
Control
PFOS
PFOA
8×10 4 6×10 4
*
4×10 4 2×10 4 0
Control
PFOS
PFOA
Control
PFOS
PFOA
3×10 4
2×10 4
1×10 4
0
cyclin D1 levels (e, f) were analyzed as described in Materials and methods. Values represent mean ± SD from three independent experiments. Statistically significant differences from control are indicated as follows: *p
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