Cotrimoxazole
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Stevens-Johnson-syndrome: case report A 50-year-old woman developed Stevens Johnson syndrome following treatment with cotrimoxazole for pneumonia. The woman presented to a hospital with a 1-day history of burning sensation in the upper half of the body with atypical flat reddish-purple target macules and papules on the face, chest and neck. This lesion later coalesced to form patches of atypical target itchy lesion over bilateral upper limbs and chest symmetrically. She also had lesions over her lips and lower limbs with the symptoms of swallowing difficulty and watery eyes. She had been treated with cotrimoxazole [route and dosage not stated] for 2 weeks due to unresolving pneumonia and had undergone wound excision procedure 2 months back. She had discontinued cotrimoxazole 3 days prior to the presentation. Her medical history was significant for diabetes and hypertension. She was on metformin, linagliptin for diabetes and losartan for hypertension. She was tachycardic. Upon examination, she was found to have multiple purpuric to atypical targetoid macules and patches over the face, chest, neck, upper limbs and trunk. Additionally, she had hemorrhagic crust with an erosion of mucosa on lips, whitish plaque over the dorsum of the tongue, and congestion of eyes with a symblepharon of the left eye. Thereafter, based on positive Nikolsky sign and tenderness with
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