Cotrimoxazole
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Syndrome of inappropriate anti-diuretic hormone secretion: case report A 62-year-old man developed syndrome of inappropriate anti-diuretic hormone secretion (SIADH) while receiving cotrimoxazole for pulmonary nocardiosis. The man was diagnosed with pulmonary nocardiosis. He started receiving oral cotrimoxazole 20 mg/kg/day in three divided doses. On the third day of the treatment, he developed hyponatraemia. After ruling out other causes of hyponatraemia, he was diagnosed with cotrimoxazole-induced SIADH. Cotrimoxazole was discontinued. Thereafter, the man’s serum sodium level normalised. Cotrimoxazole was re-initiated; however, on the day 3 of re-initiation, the man again developed hyponatraemia. Cotrimoxazole was changed to amoxicillin/clavulanic acid. After discontinuation of cotrimoxazole, his serum sodium levels normalised. Chauhan N, et al. Cotrimoxazole-induced SIADH - a unique challenge during treatment of pulmonary nocardiosis. Advances in Respiratory Medicine 88: 352-355, No. 4, 31 803503731 Aug 2020. Available from: URL: http://doi.org/10.5603/ARM.2020.0113
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Reactions 26 Sep 2020 No. 1823
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