COVID-19 and acute kidney injury in pediatric subjects: is there a place for eculizumab treatment?
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EDITORIAL
COVID‑19 and acute kidney injury in pediatric subjects: is there a place for eculizumab treatment? Hernán Trimarchi1 · Rosanna Coppo2
© Italian Society of Nephrology 2020
The coronavirus disease 2019 (COVID-19) pandemic is mostly affecting adult or elderly subjects often presenting with several co-morbidities [1]. The lack of children among the first cases described in Wuhan, China [2], and the mild disease reported in Chinese children in large series [3] have suggested that children may escape the major disease manifestations, although they can be infected. Since most cases are asymptomatic it is still unclear whether children are under-diagnosed or they are actually protected from viral invasion and overt disease. Despite these observations, recent collaborative studies have reported the development of multisystem inflammatory syndrome in children (MISC) in association with COVID-19, leading to serious and life-threatening illness [4]. Renal involvement with acute kidney injury (AKI) was detected in 5–10% of these cases. These children were treated with immunomodulatory drugs, including intravenous (i.v.) immunoglobulins, glucocorticosteroids and interleukin (IL-6 or IL-1 receptor) inhibitors. In the present issue, Mahajan et al. report a case of a 14-year-old girl with AKI associated to SARS-COV-2 infection, who developed laboratory features of thrombotic microangiopathy (TMA) and was successfully managed with the C5 inhibitor eculizumab [5]. The adolescent fulfilled the criteria for MIS-C [4]. As observed in one-third of cases with MIS-C, she had late positivity of IgG antibodies one week after initial symptoms, with negative COV-2 PCR. Inflammatory markers were elevated, respiratory distress needed intubation, myocardial and coronary involvement became manifest and dialysis-requiring AKI developed. The initial treatment choice was pragmatic and timely, including steroid pulses, i.v. immunoglobulins and the interleukin * Rosanna Coppo [email protected] 1
Nephrology Service, Hospital Británico de Buenos Aires, Buenos Aires, Argentina
Fondazione Ricerca Molinette, Regina Margherita Hospital, Turin, Italy
2
1 receptor antagonist anakinra. However, while the MIS-C slightly improved, she developed features suggestive of complement-mediated TMA, with increased Cb5-9 levels. Noteworthy, plasma C3 and C4 levels were depressed since admission. Hence eculizumab was considered as a rescue therapy aimed at controlling the progressively worsening TMA. The patient improved after the first infusion, recovered her renal function and became gradually normotensive with normal urine analysis. One of the reasons we found this case of particular interest is that it reminds us of a similar experience by one of the authors who observed a dramatic effect of eculizumab in a 4-year-old child with diffuse proliferative lupus nephritis who developed complement-mediated TMA and AKI [6]. She fully recovered but needed chronic eculizumab treatment for atypical hemolytic uremic syndrome (aHUS). Genetic studies were
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