Is there association between statin usage and contrast-associated acute kidney injury after intravenous administration o
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Is there association between statin usage and contrast-associated acute kidney injury after intravenous administration of iodine-based contrast media in enhanced computed tomography? Jae Hyon Park 1 & Hye Jung Shin 2 & Jin-Young Choi 1 & Joon Seok Lim 1 & Mi-Suk Park 1 & Myeong-Jin Kim 1 & Hyung Jung Oh 3 & Yong Eun Chung 1 Received: 3 March 2020 / Revised: 20 March 2020 / Accepted: 15 April 2020 # European Society of Radiology 2020
Abstract Objectives Contrast-induced acute kidney injury (CI-AKI) is one of the leading causes of new-onset renal failure in hospitalized patients. Statin has been evaluated for its protective effect against CI-AKI but rarely in patients receiving intravenous (IV) administrations of iodine-based contrast media for enhanced computed tomography (CT). Methods In total, 12,371 patients who underwent contrast-enhanced abdominopelvic CT were retrospectively reviewed and stratified into statin users and statin nonusers. Subgroup analyses comparing high-intensity statins with low- to moderateintensity statins were conducted within statin users and similar comparisons were performed within statin users stratified based on baseline eGFR. Results Overall, CI-AKI events did not occur less in statin users compared with non-statin users (p = 0.342). Within statin users, CI-AKI events did not decrease in high-intensity statin users compared with low- to moderate-intensity statin users (p = 0.355). Moreover, no significant difference in CI-AKI events was found between high-intensity statin users and low- to moderateintensity statin users even after stratifying the patients with baseline eGFR. Conclusions Collectively, statin was not significantly associated with the risk of CI-AKI events in patients undergoing contrastenhanced abdominopelvic CT and high-intensity statins did not show significant association with CI-AKI over low- to moderateintensity statins in the subgroup analysis. Key Points • Statin is not associated with risk of CI-AKI events in patients undergoing intravenous administration of contrast-enhanced CT. • CI-AKI incidence among high-intensity statin users was not significantly different from that of low- to moderate-intensity statin users. Keywords Contrast material . Renal insufficiency . Glomerular filtration rate . Incidence . Multidetector computed tomography
Hyung Jung Oh and Yong Eun Chung contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00330-020-06897-4) contains supplementary material, which is available to authorized users. * Hyung Jung Oh [email protected] * Yong Eun Chung [email protected] 1
Department of Radiology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
2
Department of Biomedical Systems Informatics, Biostatics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea
3
Nephrology Department, Sheikh Khalifa Specialty Hospital, P.O.Box 6365, Al Shohadaa Road, Ras al Khaimah, United Arab Emirate
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