Cryptococcosis and Tuberculosis Coinfection in a Regional Reference Service of HIV-AIDS from Southern Brazil
- PDF / 437,166 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 87 Downloads / 193 Views
MEDICINE
Cryptococcosis and Tuberculosis Coinfection in a Regional Reference Service of HIV-AIDS from Southern Brazil Lurdeti Bastos da Silva 1 & Gabriel Baracy Klafke 2,3 & Vanice Rodrigues Poester✉ 1,2,3 & Karine Ortiz Sanchotene 1 & Ivy Bastos Ramis 1,2 & Pedro Eduardo Almeida da Silva 1,2 & Rossana Patricia Basso 1,2 & Jussara Maria Silveira 2 & Melissa Orzechowski Xavier 1,2,4,3 Accepted: 29 September 2020 # Springer Nature Switzerland AG 2020
Abstract Cryptococcosis (Cr) and tuberculosis (TB) are infectious diseases potentially fatal to HIV-AIDS patients, and coinfection with Cr/TB in endemic regions may represent a new challenge in the panorama of the HIV-AIDS pandemic. This retrospective study aims to describe the clinic-epidemiological data of cryptococcosis and tuberculosis (Cr/TB) coinfection in HIV-AIDS patients from Southern Brazil. A retrospective study including all cases of coinfection by the Cryptococcus neoformans species complex and Mycobacterium tuberculosis, diagnosed in HIV-AIDS patients at the Specialized Customer Service of University Hospital - Federal University of Rio Grande (SAE-HU-FURG), during the period January 2010 to December 2012 was performed. During the 3 years of study, ten cases of Cr/TB coinfection were detected. The mean age was 39.3 years and 80% were male. Cr meningitis with pulmonary TB occurred in 40% of the cases and pulmonary presentation in both diseases occurred in 30%. The mean TCD4 + rate was 118.6 cel/mm3 (SD = 135.36), with 80% of the patients maintaining TCD4 + < 100 cells/mm3. The viral load presented by 70% of the patients was equal or higher than 100,000 copies/mm3. Four patients (40%) died on an average, 29 days (SD = 8.75) after diagnosis of the coinfection. The study shows the necessity of a broad diagnostic investigation in the context of Cr/TB/HIV-AIDS coinfection. Keywords Cryptococcus neoformans . Mycobacterium tuberculosis . Coinfection (HIV-AIDS) . Mycoses . Neglected diseases
Introduction Cryptococcosis (Cr) and tuberculosis (TB) are infectious diseases potentially fatal to patients with acquired immunodeficiency syndrome (AIDS) by human immunodeficiency virus This article is part of the Topical Collection on Medicine * Vanice Rodrigues Poester✉ [email protected] 1
Post-graduation Program in Health Science, Faculty of Medicine, Federal University of Rio Grande (FAMED-FURG), Rio Grande, Rio Grande do Sul, Brazil
2
FAMED-FURG, Rio Grande, RS, Brazil
3
Mycology Lab, Faculty of Medicine, Federal University of Rio Grande, Health Campus, Visconde de Paranaguá 102, Centro, Rio Grande, RS 96201-900, Brazil
4
Post-Graduation Program in Parasitology, Federal University of Pelotas (UFPel), Rio Grande, RS, Brazil
(HIV) infection. Both are widely distributed around the world and their diagnosis is recognized as a defining condition for AIDS [1–3]. Cr is a systemic mycosis caused by the Cryptococcus species, which presents with the main etiologic agents, C. gattii (serotypes B and C) and C. neoformans species complex (C. neoformans var. grubii, C. neof
Data Loading...
