Current Topics in Microbiology and Immunology
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Volume 47 Edited by W. Arber, Geneve . W. Braun, New Brunswick . F. Cramer, Gottingen . R. Haas, Freiburg . W. Henle, Philadelphia
. P. H. Hofschneider, Munchen
. N. K. ferne,
Frankfurt· P. Koldovsky, Prague· H. Koprowski, Philadelphia . O. Maal8c, Copenhagen . R. Rott, Giejfen L.
Syru~ek,
. H.-G. Schweiger, Wilhelmshaven . M. Sela, Rehovoth
Prague· P. K. Vogt, Seattle· E. Wecker, Wurzburg
Springer-Verlag Berlin· Heidelberg. New York 1969
ISBN-J3: 978-3-642-46162-0 DOl: 10.1007/978-3-642-46160-6
e-ISBN- \3: 978-3-642-46160-6
All rights reserved. No part of this book may be translated or reproduced in any form without written permission from SpringerVerlag. © by Springer-Verlag Berlin' Heidelberg 1969. Library of Congress Catalog Card Number 15-12910. The use of general descriptive names, trade names, trade marks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. Title No. 4695 Softcover reprint of the hardcover 1st edition 1969
Table of Contents W. C. WILCOX, and G. H. COHEN, The Poxvirus Antigens.
R. BREZINA, Advances in Rickettsial Research. With 2 Figures
1 20
H. SCHUSTER, Die molekularen Grundlagen der Photoreaktivierung. Mit 7 Abbildungen . . . . . . . . . . . . . . . . . . . . . . . . 40
L. HORTA-BARBOSA, D. FUCCILLO, and ]. L. SEVER, Rubella Virus. With
3 Figures. . . . . . . . . . . . . . . . .
69
E. NETER, Endotoxins and the Immune Response
82
OLGA KRIZANOVA, and VOJTA RATHOVA, Serum Inhibitors of Myxoviruses. With 5 Figures . . . . . . . . . . . . . . . . . . . . 125 D. F. H. WALLACH, Cellular Membrane Alterations in Neoplasia: A Review and a Unifying Hypothesis 152 Author Index .
177
SUbject Index.
202
School of Veterinary Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104
The Poxvirus Antigens WESLEY C. WILCOX, and GARY H. COHEN
* **
Table of Contents I. Introduction . . . . . . . . . . . . . . II. The Number of Poxvirus Antigens . . . . Present Status of the NP and LS Antigens. III. Sequential Synthesis of Poxvirus Antigens . IV. Location of the Poxvirus Antigens within the Virion V. Functions of the Poxvirus Antigens. . . . . . . . Cytotoxic Effects. . . . . . . . . . . . . . . . Switch-Off of Host Cell DNA and Protein Synthesis Uncoating . . . . . . . . . . . . Other Functions . . . . . . . . . Production of Neutralizing Antibody VI. Separation of Poxvirus Antigens. . VII. Poxvirus Enzymes . . . . . . . . VIII. Serological Relationships between Poxviruses . XI. Summary and Comments References. . . . . . . . .
1 2 4 4
6 7 8 8 9 9 10 10 12 13 14
16
I. Introduction Only a short time has elapsed since the poxvirus literature was reviewed in a most thorough and comprehensive fashion (J OKLIK, 1966). It is the purpose of this communication to focus in somewhat more detail on a single facet of the overall picture, the poxvirus-coded proteins or antigens. The reader will note that not
