Current Topics in Microbiology and Immunology Volume 80
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Edited by W. Arber, Basle . W. Henle, Philadelphia· P.H. Hofschneider, Martinsried . J.H. Humphrey, London . J. Klein, Dallas . P. Koldovsky, Düsseldorf . H. Koprowski, Philadelphia . O. Maaloe, Copenhagen . F. Melchers, Basle . R. RoH, Gießen· H.G. Schweiger, Wilhelmshaven . L. Syrucek, Prague . P.K. Vogt, Los Angeles
With 31 Figures
Springer-Verlag Berlin Heidelberg New York 1978
ISBN-13: 978-3-642-66958-3 e-ISBN-13: 978-3-642-66956-9 DOI: 10.1007/978-3-642-66956-9
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under §54 of the German Copyright Law where copies are made for other private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher. © by Springer-Verlag Berlin Heidelberg 1978. Softcover reprint ofthe hardcover 1st edition 1978 Library of Congress Catalog Card Number 15-12910. The use of registered names, trademarks, etc. in this publication, does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective la ws and regulations and therefore free for general use.
Table of Contents
Bullen, J.J., Rogers, H.J., and Griffiths, E.: Role of Iron In Bacterial Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . Playfair, lH.L.: Effective and Ineffective Immune Responses to Parasites: Evidence from Experimental Models. . . . . . . . . . . . . . .
37
Pearson, G.R.: In Vitro and in Vivo Investigations on Antibody-Dependent Cellular Cytotoxicity. . . . . . . . . . . . . . . . . . . . . .
65
Cohen, S., MitchelI, G.H.: Prospects for Immunisation Against Malaria
97
Scholtissek, C.: The Genome of the Influenza Virus Indexed in ISR
139
Role of Iron in Bacterial Infection 1.1.
BULLEN, HENRY
1.
ROGERS
and E.
GRIFFITHS 1
Introduction . . . . . . . . . . . . . . .
I
I. Properties of the Iron-Binding Proteins . A. Role of Transferrin in Iron Transport B. Lactoferrin and the Hypoferremia of Infection .
2
H. Iron-Binding Pro teins and Resistance to Infection. A. Yersinia pestis and Pasteurella septica B. Clostridium we1chii Type A C. Pseudomonas aeruginosa .... . ........ . D. Escherichia coli E. Protective Effect of Colostrum and Milk F. Miscellaneous Organisms . . . . . I. Listeria monocytogenes . . . . . . 2. Candida albicans and Other Fungi 3. Mycobacteria . . . . . . . . . . 4. Vibrio cholerae and Neisseria meningitidis 5. Neisseria gonorrhoeae ....... .
6 8 9 11 12
5 5
13
15 15 16 16 16 16
III. Iron-Binding Proteins in Polymorphonuc1ear Leukocytes .
17
IV. Clinical Aspects of Altered Iron Metabolism .
19
V. Biochemistry of Bacterial Inhibition. A. Pasteurella septica B. Escherichia coli VI. Conclusions References. . .
21 21 23
27 27
Introduction Iron is essential for most living things. The importance of the metal lies in its rem
