Cytoskeletal and Extracellular Proteins Structure, Interactions and
In this volume the contributions of the 2nd International EBSA (European Biophysical Societies Association) Symposium devoted to the biophysical and biochemical aspects of the structure and interaction of cytoskeletal and extracellular proteins are presen
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Springer Series in Biophysics Volume 1 Structure, Dynamics and Function of Biomolecules Edited by A. Ehrenberg, R. Rigler, A. Griislund and L. Nilsson (1987) Volume 2 Biophysics and Synchrotron Radiation. Edited by A. Bianconi and A. Congiu Castellano (1987) Volume 3 Cytoskeletal and Extracellular Proteins Edited by U. Aebi and J. Engel (1989) Volume 4 Electron-Probe Microanalysis Edited by K. Zierold and H. K. Hagler (1989)
U. Aebi
1. Engel (Eds.)
Cytoskeletal and Extracellular Proteins
Structure, Interactions and Assembly The 2nd International EBSA Symposium
With 149 Figures
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo
Professor Dr. UELI AEBl Maurice E. Miiller-Institut Biozentrum der Universitat Basel KlingelbergstraBe 70 CH-4056 Basel Professor Dr. JORGEN ENGEL Abteilung fUr Biophysikalische Chemie Biozentrum der Universitat Basel KlingelbergstraBe 70 CH-4056 Basel
ISBN-13:978-3-642-73927-9 e-ISBN-13:978-3-642-73925-5 DOl: 10.1007/978-3-642-73925-5 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re·use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its version of June 24, 1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. © Springer· Verlag Berlin Heidelberg 1989 Softcover reprint of the hardcover 1st edition 1989 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
213113145-543210 - Printed on acid·free paper
Preface
Cytoskeletal and extracellular matrix proteins have many features in common regarding their 3-dimensional structure, interactions and assembly properties. In- and outside the cell filaments, fibres and more complex supramolecular assemblies are in dymanic equilibrium with molecular building blocks exhibiting many common structural motifs and having a high potential for in vitro self-assembly. In addition, the two systems can communicate with each other through receptor molecules spanning the plasma membrane and interacting via their extracellular and cytosolic domains with specific components of the two. Biophysical research has made substantial contributions to our present knowledge and understanding of the often complex biological functions and interactions of the cytoskeleton and the extracellular matrix. The three-dimensional structure of the constituent proteins, the dynamics of their interactions, the thermodynamics of assembly and the mechanisms of regulatory processes, as well as the architecture and molecular organization of complex structures all represent problems that are appro
