ZIKV viral proteins and their roles in virus-host interactions
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KV viral proteins and their roles in virus-host interactions 1
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Moujian Guo , Lixia Hui , Yiwen Nie , Boris Tefsen & Ying Wu 1
State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; 2 Department of Biological Sciences, Xi’an Jiaotong-Liverpool University, Suzhou 215123, China; 3 Hubei Province Key Laboratory of Allergy and Immunology, Wuhan 430071, China Received June 6, 2020; accepted September 12, 2020; published online October 14, 2020
The re-emergence of Zika virus (ZIKV) and its associated neonatal microcephaly and Guillain-Barré syndrome have led the World Health Organization to declare a global health emergency. Until today, many related studies have successively reported the role of various viral proteins of ZIKV in the process of ZIKV infection and pathogenicity. These studies have provided significant insights for the treatment and prevention of ZIKV infection. Here we review the current research advances in the functional characterization of the interactions between each ZIKV viral protein and its host factors. ZIKV, viral protein, host-virus interactions, immune response, pathogenicity Citation:
Guo, M., Hui, L., Nie, Y., Tefsen, B., and Wu, Y. (2020). ZIKV viral proteins and their roles in virus-host interactions. Sci China Life Sci 63, https:// doi.org/10.1007/s11427-020-1818-4
Introduction Zika virus (ZIKV) is a mosquito-borne flavivirus that can cause Zika Fever, the Guillain-Barré syndrome (GBS) in adults and microcephaly in fetuses and infants (Johansson et al., 2016; Pierson and Diamond, 2018). ZIKV was first isolated from a rhesus monkey with fever in Zika Forest, Entebbe, Uganda, in 1947 (Dick and Haddow, 1952; Dick et al., 1952). At the outset, ZIKV was only circulating in Africa, and fewer than 20 human infections had been documented for half a century (Faye et al., 2014). In 2007, the first outbreak of ZIKV occurred on Yap Island in the Western Pacific Micronesia, causing approximately 3/4 of the residents to be infected with ZIKV, and the patients had only mild symptoms such as rash, fever, joint pain and conjunctivitis (Duffy et al., 2009; Musso and Gubler, 2016). From October 2013 to March 2014, French Polynesia experienced a large-scale Zika virus infection. Unlike the past, in this epidemic there were cases of GBS reported to be
related with ZIKV infection for the first time (Cao-Lormeau et al., 2014; Oehler et al., 2014). The largest outbreak of ZIKV infection in history started in Brazil in 2015, and subsequently the virus infections rapidly expanded to many countries in the Americas (Fauci and Morens, 2016). As of 2017, more than 22,000 confirmed cases and 580,000 suspected cases have been reported in 52 American countries and regions (Pierson and Diamond, 2018). Due to the neonatal microcephaly and GBS associated with ZIKV infections in the American ZIKV epidemic, ZIKV received widespread international attention (de Oliveira et al., 2017; Johansson et al., 2016). ZIKV belongs to the genus of Flavivirus in the fami
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