Dendrimer-Based Tumor-targeted Systems
Dendrimers have a unique three-dimensional structure, highly branched macromolecular features, and abundant terminal functional groups. These features of dendrimers support their uses as universal nanoplatforms to prepare multifunctional nanodevices for a
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Dendrimer-Based Tumor-targeted Systems Zhijun Ouyang, Du Li, Mingwu Shen, and Xiangyang Shi
Abstract Dendrimers have a unique three-dimensional structure, highly branched macromolecular features, and abundant terminal functional groups. These features of dendrimers support their uses as universal nanoplatforms to prepare multifunctional nanodevices for a myriad of biomedical applications, particularly for targeted imaging and therapy of different biosystems. The periphery of the dendrimer enables the attachment of targeting ligands and imaging agents, while the internal cavity allows the embedment of metal nanoparticles (NPs), anticancer drugs, and other inorganic NPs. Meanwhile, the versatile dendrimer nanotechnology enables different types of integration with varied inorganic components. The resulting hybrid dendrimer-based particles are useful in a variety of imaging, therapy, or theranostic applications. This chapter focuses on the latest advances in the dendrimer-based targeting systems for the imaging, therapy, and theranostics of cancer. Keywords Dendrimers · Targeting · Contrast agents · Therapy · Theranostic agents
Abbreviations 3D 99m
Tc α-TOS AuNPs AFM Au DENPs-FA ASGPR BBB bis-MPA
3-dimensional Technetium-99m α-tocopheryl succinate Gold nanoparticles Atomic force microscopy Folic acid-modified dendrimer-entrapped gold nanoparticles Asialoglycoprotein receptors Blood brain barrier 2,2-bis(hydroxymethyl)propionic acid
Z. Ouyang · D. Li · M. Shen · X. Shi (*) State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-dimension Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People’s Republic of China e-mail: [email protected] © Springer Nature Singapore Pte Ltd. 2020 R. Huang, Y. Wang (eds.), New Nanomaterials and Techniques for Tumor-targeted Systems, https://doi.org/10.1007/978-981-15-5159-8_10
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CT DOTA DOTA-NHS DTPA DENPs/DSNPs DOX EPR EGFP FA FAR FA-PEG-COOH FI FDG FAM FPP Gd-Au DENPs G Gal HA HPAO hMSCs HER2 HEGFR HCC HUVEC IO IL-6 LA LA-Au DENPs Luc MR MWCNTs mPEG-COOH NCPs PEG NAcGal PAMAM PLL PPI PSMA PET PGA
Z. Ouyang et al.
Computer tomography Tetraazacyclododecane-1,4,7,10-tetraacetic acid (2,20 ,200 -(10-(2-(2,5-dioxopyrrolidin-1-yloxy)-2-oxoethyl)1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid Diethylenetriaminepentaacetic acid Dendrimer-entrapped nanoparticles/dendrimer-stabilized nanoparticles Doxorubicin Enhanced permeability and retention Enhanced green fluorescent protein Folic acid FA receptors PEG-modified FA with carboxyl end group Fluorescein isothiocyanate 2-18F-fluoro-2-deoxy-D-glucose Fluorescein amidite FA-PEG-PAMAM Gd-loaded Au DENPs Generation Galactose Hyaluronic acid 3-(4’-hydroxyphenyl) propionic acid-OSu Human mesenchymal stem cells Human epidermal growth factor receptor-2 Human epidermal growth factor receptor Hepatocellular carcinoma Human umbilical vein endothelial cells Iron oxide Interleukin-6 Lactobionic acid LA-mod
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