Developed methods for the preparation of electrospun nanofibers containing plant-derived oil or essential oil: a systema
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Developed methods for the preparation of electrospun nanofibers containing plant‑derived oil or essential oil: a systematic review Mahmoud Osanloo1,2 · Javad Arish2 · Hassan Sereshti3 Received: 10 September 2019 / Revised: 25 November 2019 / Accepted: 29 November 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Recently, natural health products as alternatives for synthetic/chemical substances have become a growing area of interest. Plant-derived essential oils or oils (E/ Os) with a wide range of bioactivities such as anticancer, antibacterial, antifungal, and antioxidant activities are widely used among natural materials. Furthermore, nanofibers (NFs) with distinct properties, including large surface area, many available ingredients for preparation, and various preparation methods have attracted much attention. The present systematic review is an attempt to collect and document the recent studies from 01.01.2013 to 31.12.2018, indicating the loading of E/O in electrospun NFs. First, a summary of the electrospinning process and applications of electrospun NFs in medicine were given. Then, the three manners, which have been introduced for preparing E/O-loaded NFs so far, were described. Moreover, the main techniques for characterization of such NFs, e.g., evaluation of size and morphology, determination of the loaded amount of E/O in NFs, and investigating their release behavior, were explained.
* Mahmoud Osanloo [email protected]; [email protected] 1
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
2
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
3
Department of Chemistry, Faculty of Science, University of Tehran, Tehran, Iran
13
Vol.:(0123456789)
Polymer Bulletin
Graphic abstract
Keywords Essential oil · Electrospun · Nanofibers · Electrospinning · A systematic review
Nanotechnology Nanotechnology is defined as targeted manipulations of materials in nanoscale for obtaining size-dependent features or functions [1]. The most common nanomaterials include metallic nanoparticles [2, 3], nanoemulsions [4] polymeric nanoparticle [5, 6], lipidic nanocarrier [7], and nanofibers (NFs) [8]. NFs (diameter ~ 200 nm) with small pores and large surface areas have enormous applications in medicine, such as tissue engineering, drug delivery, and wound dressing [9]. Various techniques, including template-assisted synthesis, electrospinning, phase separation, self-assembly, solvent casting, and drawing–processing, were developed for the fabrication of NFs based on a literature review [10–12]. Electrospinning is a versatile and easily adaptable technique and the most common method for the preparation of NFs [13–15]. Electrospinning, compared with other approaches such as phase separation and self-assembly, has the advantages of versatility and flexibility in the selection of material and control over fibers’ morphology and diameter [16]. The preparatio
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