Development of the Cerebellum from Molecular Aspects to Diseases
The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Know
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Hassan Marzban Editor
Development of the Cerebellum from Molecular Aspects to Diseases 123
Contemporary Clinical Neuroscience Series Editor Mario Manto, Unité d’Etude du Mouvement (UEM), FNRS, Neurologie ULBErasme, Bruxelles, Belgium
More information about this series at http://www.springer.com/series/7678
Hassan Marzban Editor
Development of the Cerebellum from Molecular Aspects to Diseases
Editor Hassan Marzban Department of Human Anatomy and Cell Science The Children’s Hospital Research Institute of Manitoba (CHRIM) Max Rady College of Medicine, Rady Faculty of Health Science University of Manitoba Winnipeg, MB, Canada
Contemporary Clinical Neuroscience ISBN 978-3-319-59748-5 ISBN 978-3-319-59749-2 (eBook) DOI 10.1007/978-3-319-59749-2 Library of Congress Control Number: 2017946076 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
For the past centuries, scientists have worked hard to understand the development of the cerebellum and its disorders. Cerebellar neurodevelopmental disorders are impairments of the growth and development of the cerebellum that result in birth defects that may have a severe impact on patients’ lives. A narrower use of the term refers to a disorder that unfolds during individual development to affect motor function, emotion, learning ability, self-control, and memory. Knowledge obtained from advanced neuroimaging techniques and from molecular and genetic studies has provided rapidly growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Advanced technologies for research have changed our views of cere
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