Molecular Pathology of Endocrine Diseases
The Molecular Pathology Library Series fills the gap between basic science and clinical application. Each user-friendly reference brings together diverse topics about molecular pathogenesis, diagnosis and treatment in one volume. The series serves physici
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Molecular Pathology of Endocrine Diseases Edited by
Jennifer L. Hunt
Massachusetts General Hospital, Boston, MA, USA
Editor Jennifer L. Hunt Massachusetts General Hospital Boston, MA USA
ISBN 978-1-4419-1706-5 e-ISBN 978-1-4419-1707-2 DOI 10.1007/978-1-4419-1707-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010921196 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Series Preface
The past two decades have seen an ever accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Molecular diagnostics, molecular targeted therapy, and genetic therapy are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, medical oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical investigators, pathologists and medical laboratory directors, and radiologists require a basic understanding of the fundamentals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical setting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is
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