Diallyl Sulfide and Its Role in Chronic Diseases Prevention
Diallyl sulfide (C6H10S, DAS) is one of the novel natural organosulfur compounds, which is mostly obtained from the genus Allium plants. Numerous studies have revealed several unique properties of DAS in terms of its health-promoting effects. DAS has prov
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Abstract Diallyl sulfide (C6H10S, DAS) is one of the novel natural organosulfur compounds, which is mostly obtained from the genus Allium plants. Numerous studies have revealed several unique properties of DAS in terms of its health-promoting effects. DAS has proved to be anticancer, antimicrobial, anti-angiogenic, and immunomodulatory like unique functions as demonstrated by the multiple investigations. Diallyl sulfide can also impede oxidative stress and chronic inflammation as suggested by the literature. Studies also explored that DAS could thwart the development of chronic diseases like cancer, neuronal, cardiovascular disease through modulating mechanistic pathways involved in pathogenesis. In this book chapter, we have attempted to give the comprehensive view on DAS about the physiochemical and biological properties, and its preventive role in chronic diseases with a mechanistic overview. Keywords Diallyl sulfide activities
Chronic disease Signaling pathways Biological
1 Introduction Diallyl sulfide (C6H10S) is a lipophilic thioallyl-ether and one of the organosulfur compounds extracted most commonly from garlic (Allium sativam L.). From the late nineteenth century, organosulfur compounds are recognized as the pungent smelling material of garlic, and diallyl sulfide is one of the components of distilled garlic oil [1]. Diallyl sulfide is one among the dietary phytochemicals, which showed many beneficial health effects in various experimental studies [2–4]. There is a growing body of literature, where the implications of diallyl sulfide in various chronic diseases, including cancer, neuronal, cardiovascular, liver, and numerous S. Suman Y. Shukla (&) Food, Drug and Chemical Toxicology Division, CSIR-Indian Institute of Toxicology Research, 31, Vish Vigyan Bhawan, M.G. Marg, Lucknow 226001, UP, India e-mail: [email protected] © Springer International Publishing Switzerland 2016 S.C. Gupta et al. (eds.), Drug Discovery from Mother Nature, Advances in Experimental Medicine and Biology 929, DOI 10.1007/978-3-319-41342-6_6
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S. Suman and Y. Shukla Beneficial health effects of diallyl sulfide
Sr. No.
Effects
Studies
References
1
Antioxidant activities
[8, 91, 92]
2
Protection against coronary heart disease Antimicrobial activity
Oral administration protects against pentachlorophenol-induced oxidative damage Modulate GSH-related antioxidant system reacting with free radical generated by UVC-activated hydrogen peroxide Long-term administration inhibits platelet aggregation Protect LDL for oxidation and glycation Against gram-positive and gram-negative bacterial Against Helicobacter pyroli and Pseudomonas aerogenosa Reduce mutagenicity of styrene oxide and 4-nitroquinoline-1-oxide in Ames test Inhibited micronuclei formation Antimutagenic potential of cyclophosphamide-induced chromosomal aberration Diallyl sulfide-modulated interleukin (IL)1beta, and IL-6 and IL-10 Inhibit two-stage tumorigenesis in mouse skin tumorigenesis
3
4
Antimutagenic activities
5
Immunomodulatory Mechanism Antic
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