Diclofenac
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Various toxicities: case report A 50-year-old woman developed breathlessness, abdominal distention, fever, chills, rigors, pain in both legs, pedal oedema and headache during treatment with diclofenac for body pain. The woman presented to hospital in India with fever, chills, rigors and a 5-day history of pain in both legs and bilateral pedal oedema. She had no history of vomiting and motions. Along with this, she had breathlessness, abdominal distention, headache and body aches. She had been receiving diclofenac [route, dosage and duration of treatment to reaction onset not stated] from the previous 1 year for body pains. On examination, she was conscious and coherent. Her vital signs were as follows: blood pressure 110/80mm Hg, pulse rate 105 bpm, fever (101) febrile [unit not stated] and SPO2 91%. Systemic examination revealed RS B/L wheeze positive, P/A soft, distended. CVS-S1,S2 positive and CNS NAD. Laboratory examination revealed WBC 13000 cells/cumm, in which neutrophils 80% and eosinophils 8%. ESR level was found elevated. Haemoglobin level was found to be 10 gm/dL, and renal function test showed elevated level of creatinine. The woman received ceftriaxone, pantoprazole, paracetamol, albuterol [astalin] and oxygen inhalation. After 5 days, parenteral therapy was stopped gradually, and she showed steady improvement. She was discharged with cefixime, paracetamol, ranitidine [rantac], sucralfate and salbutamol. Ascharya Ch, et al. Diclofenac induced breathlessness and abdominal distension-a case report. Journal of Global Trends in Pharmaceutical Sciences 11: 8500-8502, No. 4, Oct 803516682 2020. Available from: URL: https://www.jgtps.com/issue.php?id=NDc=
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Reactions 21 Nov 2020 No. 1831
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