Fabrication of Microdispersed Tissue-Specific Decellularized Matrix from Porcine Articular Cartilage
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RIALS FOR ENSURING HUMAN VITAL ACTIVITY AND ENVIRONMENTAL PROTECTION
Fabrication of Microdispersed Tissue-Specific Decellularized Matrix from Porcine Articular Cartilage Yu. B. Basoka, *, A. D. Kirillovaa, **, A. M. Grigoryeva, ***, L. A. Kirsanovaa, ****, E. A. Nemetsa, *****, and V. I. Sevastianova, ****** a
Shumakov Federal Research Center of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow, 123182 Russia *e-mail: [email protected] **e-mail: [email protected] ***e-mail: [email protected] ****e-mail: [email protected] *****e-mail: [email protected] ******e-mail: [email protected]
Received February 2, 2020; revised February 26, 2020; accepted February 27, 2020
Abstract—A method for obtaining a microdispersed tissue-specific matrix from decellularized porcine articular cartilage while maintaining morphological and functional properties of the extracellular matrix with no signs of cytotoxicity was developed. The cartilage particle size distribution in suspension after cryogenic grinding was determined using laser diffraction analysis. The range of sizes of the obtained cartilage microparticles suggests the possibility of their administration by injection (
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