Does measuring early basal serum follicular lutinising hormone assist in predicting In vitro fertilization (IVF)/Intracy
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BioMed Central
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Does measuring early basal serum follicular lutinising hormone assist in predicting In vitro fertilization (IVF)/Intracytoplasmic sperm injection (ICSI) outcome? Ahmed Kassab*, Luca Sabatini, Gidon Lieberman, Amanda Tozer, Ariel Zosmer, Colin Davis and Talha Al-Shawaf Address: Barts and The London Centre for Reproductive Medicine, Kenton and Lucas Block, St Bartholomew's Hospital, Barts and The London NHS Trust, West Smithfield, London EC1A 7BE, UK Email: Ahmed Kassab* - [email protected]; Luca Sabatini - [email protected]; Gidon Lieberman - [email protected]; Amanda Tozer - [email protected]; Ariel Zosmer - [email protected]; Colin Davis - [email protected]; Talha Al-Shawaf - [email protected] * Corresponding author
Published: 20 July 2007 Reproductive Biology and Endocrinology 2007, 5:32
doi:10.1186/1477-7827-5-32
Received: 4 March 2007 Accepted: 20 July 2007
This article is available from: http://www.rbej.com/content/5/1/32 © 2007 Kassab et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: The aim was to examine the correlation of early follicular serum lutinising hormone (LH) and the clinical outcome of assisted reproduction technique (ART). Methods: An observational study included 1333 consecutive women undergoing invitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). 964 women were having their first cycle of ART. Data were entered prospectively. All women had serum LH measured in the 6 months before the index cycle studied. No repeat cycles were included. The main outcomes measured were clinical pregnancy (CP) and live birth (LB) correlation to serum LH. Forward multivariate stepwise regression analysis was applied, and other statistical tests were used as appropriate. Results: There was non significant correlation between basal serum LH and CP and LB in the polycystic ovary syndrome group (R2 = 0.02, F = 1.7 and P = 0.76) (R2 = 0.01, F = 2.6 and P = 0.77) respectively after adjusting for age, BMI, day of oocyte retrieval, starting dose, total dose of stimulation, type of gonadotrophin used, number of oocytes retrieved, fertilization rate and number of embryos transferred. Other aetiological causes group there was similarly non significant correlation between basal serum LH and CP (R2 = 0.05, F = 13.1 and P = 0.66), nor for LB (R2 = 0.007, F = 4.5 and P = 0.9). Conclusion: Early follicular serum LH measurements in the 6 months before IVF/ICSI treatment cycle did not correlate with the clinical pregnancy or the live birth rate.
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Reproductive Biology and Endocrinology 2007, 5:32
Background Controversy and debate still exist in
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