Doxycycline
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Spongiotic oesophagitis associated with eosinophilic vascular degeneration: case report A 64-year-old man developed spongiotic oesophagitis associated with eosinophilic vascular degeneration following treatment with doxycycline. The man, who had reflux symptoms, developed new-onset dysphagia. He had been receiving doxycycline 100mg once daily since two weeks for rosacea [route not stated]. Her concomitant medications included rosuvastatin, esomeprazole and amlodipine. Endoscopy showed oesophagitis with ulceration in the distal third and a small ulcer distal to the gastroesophageal junction (GEJ) with mild gastritis and a mild duodenitis. Following a month, second endoscopy showed a persistent flat ulcer in the midoesophagus. After three months, a third endoscopy showed mucosal sloughing of the distal oesophagus with underlying ulceration. Microscopy showed erosive oesophagitis with ulceration, zonal infarction of the basal epithelium and lamina propria of the distal oesophagus, spongiosis and heavy neutrophilic inflammation. The superficial lamina propria exhibited an exuberant suppurative inflammation along with scattered eosinophils, histiocytes and lymphocytes. Based on these findings, doxycycline-induced spongiotic oesophagitis associated with eosinophilic vascular degeneration was considered. The man’s treatment with doxycycline was discontinued. Within a few weeks, the symptoms resolved. Medlicott SAC, et al. Doxycycline-induced spongiotic oesophagitis is associated with eosinophilic vascular degeneration. Histopathology : Jan 2020. Available from: URL: 803501499 http://doi.org/10.1111/his.14177
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Reactions 19 Sep 2020 No. 1822
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