Mouse Models for Drug Discovery Methods and Protocols
With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of
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Gabriele Proetzel Michael V. Wiles Editors
Mouse Models for Drug Discovery Methods and Protocols Second Edition
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Mouse Models for Drug Discovery Methods and Protocols Second Edition
Edited by
Gabriele Proetzel Takeda Pharmaceutical Company, Cambridge, MA, USA
Michael V. Wiles The Jackson Laboratory, Bar Harbor, ME, USA
Editors Gabriele Proetzel Takeda Pharmaceutical Company Cambridge, MA, USA
Michael V. Wiles The Jackson Laboratory Bar Harbor, ME, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3659-5 ISBN 978-1-4939-3661-8 (eBook) DOI 10.1007/978-1-4939-3661-8 Library of Congress Control Number: 2016933104 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface The cost of drug development continues to climb, reaching in 2014 an estimated $2.6 billion per approved compound to reach market. A major cost contributor in this exorbitant expense is the number of potential drugs that fail during clinical development. Recently, it has been suggested that this high failure rate can perhaps be addressed, at least in part, by improving preclinical research with a focus on more accurate and imaginative use of animal models and a greater understanding of the role of genetics in drug interactions. Linked with this, and as our understanding of disease biology grows deeper, animals models are growing in sophistication and are increasingly more capable of emulating aspects of human disease. Combined, these developments are having a positive impact in reducing or at least slowing the drug development cost spiral. It i
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