Effect of gabapentin on sleep-deprivation-induced disruption of prepulse inhibition
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ORIGINAL INVESTIGATION
Effect of gabapentin on sleep-deprivation-induced disruption of prepulse inhibition Fatma Duygu Kaya-Yertutanol 1
&
İ. Tayfun Uzbay 1 & Burcu Çevreli 1 & Hayrunnisa Bolay-Belen 2
Received: 4 September 2018 / Accepted: 11 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Rationale There are controversial reports on the effects of gabapentin in respect to psychotic symptoms. Prepulse inhibition of the acoustic startle response is an operational measure of sensorimotor gating. In laboratory rodents, deficits in sensorimotor gating are used to model behavioral endophenotypes of schizophrenia. Sleep deprivation disrupts prepulse inhibition and can be used as a psychosis model to evaluate effects of gabapentin. Objectives This study aimed to investigate behavioral effects of gabapentin in both naïve and sleep-deprived rats. Methods Sleep deprivation was induced in male Wistar rats by using the modified multiple platform technique in a water tank for 72 h. The effect of water tank itself was studied in a sham group. The effects of oral acute and subchronic (4.5 days) gabapentin doses (25, 100, or 200 mg/kg/day) on sensorimotor gating and locomotor activity was evaluated by prepulse inhibition test and locomotor activity test, respectively. Plasma gabapentin levels of some groups and body weights of all groups were also assessed. Results Sleep deprivation disrupted prepulse inhibition, increased locomotor activity, reduced gabapentin plasma levels, and body weights. Some gabapentin doses disrupted sensorimotor gating irrespective of sleep condition. Some gabapentin doses increased locomotor activity in non-sleep-deprived rats and decreased locomotor activity in sleep-deprived rats. On the contrary, gabapentin did not normalize sleep deprivation-induced disruption in sensorimotor gating. Conclusions Sleep deprivation via modified multiple platform technique could be used as an animal model for psychosis. Gabapentin may have dose- and duration-dependent effects on sensorimotor gating and locomotor activity. Keywords Sleep deprivation . Gabapentin . Rat . Prepulse inhibition . Sensorimotor gating
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00213-020-05587-9) contains supplementary material, which is available to authorized users. * Fatma Duygu Kaya-Yertutanol [email protected] İ. Tayfun Uzbay [email protected] Burcu Çevreli [email protected] Hayrunnisa Bolay-Belen [email protected] 1
Neuropsychopharmacology Practice and Research Center, Uskudar University, Haluk Türksoy Sokak No:14, Istanbul 34662, Turkey
2
Department of Neurology, Gazi University Faculty of Medicine, Mevlana Bulvarı No:29, Ankara 06560, Turkey
Sleep deprivation (SD) leads to schizophrenia-like changes in the brain. There are behavioral, neurophysiological, and neurochemical similarities between schizophrenia and SD states. The first similarity is the appearance of schizophrenia-like subclinical and clinical symptoms s
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